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- W2000448910 abstract "Summary Histone modifications are increasingly being recognized as important epigenetic mechanisms that govern chromatin structure and gene expression. EZH 2 is the catalytic subunit of the polycomb repressive complex 2 ( PRC 2), responsible for tri‐methylation of lysine 27 on histone 3 (H3K27me3) that leads to gene silencing. This highly conserved histone methyltransferase is found to be overexpressed in many different types of cancers including melanoma, where it is postulated to abnormally repress tumor suppressor genes. Somatic mutations have been identified in approximately 3% of melanomas, and activating mutations described within the catalytic SET domain of EZH 2 confer its oncogenic activity. In the following review, we discuss the evidence that EZH 2 is an important driver of melanoma progression and we summarize the progress of EZH 2 inhibitors against this promising therapeutic target." @default.
- W2000448910 created "2016-06-24" @default.
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- W2000448910 date "2014-06-27" @default.
- W2000448910 modified "2023-10-16" @default.
- W2000448910 title "EZH2: an emerging role in melanoma biology and strategies for targeted therapy" @default.
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- W2000448910 doi "https://doi.org/10.1111/pcmr.12280" @default.
- W2000448910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24912396" @default.
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