Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000451114> ?p ?o ?g. }
- W2000451114 endingPage "928" @default.
- W2000451114 startingPage "920" @default.
- W2000451114 abstract "We have previously reported that Monad, a novel WD40 repeat protein, potentiates apoptosis induced by tumor necrosis factor-α and cycloheximide. By affinity purification and mass spectrometry, RNA polymerase II-associated protein 3 (RPAP3) was identified as a Monad binding protein and may function with Monad as a novel modulator of apoptosis pathways. Here we report that Reptin, a highly conserved AAA + ATPase that is part of various chromatin-remodeling complexes, is also involved in the association of RPAP3 by immunoprecipitation and confocal microscopic analysis. Overexpression of RPAP3 induced HEK293 cells to death after UV-irradiation. Loss of RPAP3 by RNAi improved HeLa cell survival after UV-induced DNA damage and attenuated the phosphorylation of H2AX. Depletion of Reptin reduced cell survival and facilitated the phosphorylation on H2AX. These results suggest that RPAP3 modulates UV-induced DNA damage by regulating H2AX phosphorylation. J. Cell. Biochem. 106: 920–928, 2009. © 2009 Wiley-Liss, Inc." @default.
- W2000451114 created "2016-06-24" @default.
- W2000451114 creator A5016466003 @default.
- W2000451114 creator A5040162933 @default.
- W2000451114 creator A5042738577 @default.
- W2000451114 creator A5046360757 @default.
- W2000451114 creator A5049969219 @default.
- W2000451114 creator A5052963801 @default.
- W2000451114 creator A5065213415 @default.
- W2000451114 date "2009-04-01" @default.
- W2000451114 modified "2023-09-25" @default.
- W2000451114 title "RPAP3 interacts with Reptin to regulate UV-induced phosphorylation of H2AX and DNA damage" @default.
- W2000451114 cites W1752089945 @default.
- W2000451114 cites W1965239527 @default.
- W2000451114 cites W1965607297 @default.
- W2000451114 cites W1968203528 @default.
- W2000451114 cites W1975607252 @default.
- W2000451114 cites W1975660840 @default.
- W2000451114 cites W1976767543 @default.
- W2000451114 cites W1979139758 @default.
- W2000451114 cites W1979146983 @default.
- W2000451114 cites W1989059483 @default.
- W2000451114 cites W1990119584 @default.
- W2000451114 cites W1995569417 @default.
- W2000451114 cites W2000832682 @default.
- W2000451114 cites W2005842420 @default.
- W2000451114 cites W2013429896 @default.
- W2000451114 cites W2013590529 @default.
- W2000451114 cites W2015767192 @default.
- W2000451114 cites W2022417639 @default.
- W2000451114 cites W2023726427 @default.
- W2000451114 cites W2037147378 @default.
- W2000451114 cites W2038186997 @default.
- W2000451114 cites W2039956849 @default.
- W2000451114 cites W2041259862 @default.
- W2000451114 cites W2042412060 @default.
- W2000451114 cites W2042983294 @default.
- W2000451114 cites W2044852835 @default.
- W2000451114 cites W2049631853 @default.
- W2000451114 cites W2052190772 @default.
- W2000451114 cites W2057949133 @default.
- W2000451114 cites W2059318490 @default.
- W2000451114 cites W2059971436 @default.
- W2000451114 cites W2062581862 @default.
- W2000451114 cites W2065623019 @default.
- W2000451114 cites W2074174643 @default.
- W2000451114 cites W2080120619 @default.
- W2000451114 cites W2082559623 @default.
- W2000451114 cites W2084969545 @default.
- W2000451114 cites W2089574530 @default.
- W2000451114 cites W2090014412 @default.
- W2000451114 cites W2102752109 @default.
- W2000451114 cites W2128680272 @default.
- W2000451114 cites W2136493185 @default.
- W2000451114 cites W2144706906 @default.
- W2000451114 cites W2146085716 @default.
- W2000451114 cites W2152745581 @default.
- W2000451114 cites W2155749206 @default.
- W2000451114 cites W2162716784 @default.
- W2000451114 cites W2170396482 @default.
- W2000451114 cites W2477626371 @default.
- W2000451114 cites W4212962560 @default.
- W2000451114 doi "https://doi.org/10.1002/jcb.22073" @default.
- W2000451114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19180575" @default.
- W2000451114 hasPublicationYear "2009" @default.
- W2000451114 type Work @default.
- W2000451114 sameAs 2000451114 @default.
- W2000451114 citedByCount "22" @default.
- W2000451114 countsByYear W20004511142012 @default.
- W2000451114 countsByYear W20004511142013 @default.
- W2000451114 countsByYear W20004511142014 @default.
- W2000451114 countsByYear W20004511142015 @default.
- W2000451114 countsByYear W20004511142017 @default.
- W2000451114 countsByYear W20004511142018 @default.
- W2000451114 countsByYear W20004511142019 @default.
- W2000451114 crossrefType "journal-article" @default.
- W2000451114 hasAuthorship W2000451114A5016466003 @default.
- W2000451114 hasAuthorship W2000451114A5040162933 @default.
- W2000451114 hasAuthorship W2000451114A5042738577 @default.
- W2000451114 hasAuthorship W2000451114A5046360757 @default.
- W2000451114 hasAuthorship W2000451114A5049969219 @default.
- W2000451114 hasAuthorship W2000451114A5052963801 @default.
- W2000451114 hasAuthorship W2000451114A5065213415 @default.
- W2000451114 hasConcept C104317684 @default.
- W2000451114 hasConcept C105696609 @default.
- W2000451114 hasConcept C11960822 @default.
- W2000451114 hasConcept C134935766 @default.
- W2000451114 hasConcept C143425029 @default.
- W2000451114 hasConcept C1491633281 @default.
- W2000451114 hasConcept C153911025 @default.
- W2000451114 hasConcept C167227067 @default.
- W2000451114 hasConcept C190283241 @default.
- W2000451114 hasConcept C2777366897 @default.
- W2000451114 hasConcept C2778128677 @default.
- W2000451114 hasConcept C29537977 @default.
- W2000451114 hasConcept C3675279 @default.
- W2000451114 hasConcept C54086632 @default.
- W2000451114 hasConcept C552990157 @default.