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• W2000451530 abstract "Primitive neuroectodermal tumors are in the Ewing's sarcoma family of tumors and are composed of small round cells. Because of their rare occurrence, optimal therapy is challenging, particularly if they occur in the head and neck. Diagnosis is based on history, immunostaining with at least 2 neural markers, ultrastructural examination, and evidence of an abnormal t(11;22)(q24;q12) translocation as the hallmark for the Ewing's sarcoma family. The prognosis in general is poor because of overt metastasis at the time of diagnosis. Of 27 reported patients with primitive neuroectodermal tumors of the head and neck, 23 were less than 20 years of age. Most patients presented with a tumor in the nasal cavity, paranasal sinuses, or neck. Symptoms developed rapidly (3.6 months, on average), and a lethal outcome occurred in 9 patients. This highly malignant tumor requires an aggressive combination of radical resection, chemotherapy, and radiotherapy. A close follow-up with regular radiographic examination for at least 5 years is mandatory." @default.
• W2000451530 created "2016-06-24" @default.
• W2000451530 creator A5023682727 @default.
• W2000451530 date "2004-07-01" @default.
• W2000451530 modified "2023-10-18" @default.
• W2000451530 title "Primitive Neuroectodermal Tumor of the Head and Neck: Incidence, Diagnosis, and Management" @default.
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• W2000451530 doi "https://doi.org/10.1177/000348940411300705" @default.
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