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- W2000451704 abstract "Cytokines play an important role during labor and full- or preterm delivery. They influence physical immunity of the fetus–neonate and express a leading role in the perinatal period, being present in maternal and fetal tissues. To investigate whether cytokine concentrations in the mother, fetus and neonate depend on the labor and the mode of the delivery. Prospective study. Seventy-eight healthy, non-smoking parturients (mean age 28±4, range 21–39 years, delivering vaginally: n=52 or by elective cesarean section: n=26) and their single, healthy, appropriate for gestational age, full-term neonates. We correlated determined circulating levels of IL-2, sIL-2R, IL-4, sIL-4R, IL-6, sIL-6R, IL-1β, IL-8, IFN-γ, TNF-α, sTNF RI, sTNF RII and RANTES in the mothers before delivery (MS), the fetuses (UC) and the neonates in days 1 (N1) and 4 (N4) of life, with the mode of delivery. sIL-2R in N1 and N4, sIL-4R in MS, IL-6 in MS and UC, IL-1β in MS, UC and N1, IFN-γ in MS and UC, TNF-α in UC, N1 and N4, sTNF RI in UC were significantly higher in cases of vaginal delivery than in cases of elective cesarean section (p ranging from 0.0005 to 0.05). Vaginal delivery promotes the production of various cytokines and their receptors, which are implicated in neonatal immunity." @default.
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- W2000451704 date "2005-04-01" @default.
- W2000451704 modified "2023-10-11" @default.
- W2000451704 title "The influence of the mode of delivery on circulating cytokine concentrations in the perinatal period" @default.
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- W2000451704 doi "https://doi.org/10.1016/j.earlhumdev.2004.10.017" @default.
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