FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000452395> ?p ?o ?g. }

• W2000452395 endingPage "134" @default.
• W2000452395 startingPage "129" @default.
• W2000452395 abstract "Improved hygiene has altered early microbial exposure by reducing childhood infections, which has been suggested as a cause for the continuously rising prevalence of atopic diseases. On the basis of both intensity and timing of stimulus, it has been hypothesized that exposure to commensal microflora may represent another key protective modulator of immunity against atopy and subsequent atopic diseases.We sought to investigate whether differences in early gut microflora precede the later development of atopic sensitization.Intestinal microflora from 76 infants at high risk of atopic diseases were analyzed at 3 weeks and 3 months of age by using conventional bacterial cultivation and 2 culture-independent methods, gas-liquid chromatography of bacterial cellular fatty acids and quantitative fluorescence in situ hybridization of bacterial cells. Infants evincing at least one positive skin prick reaction at 12 months were grouped as atopic subjects, and those without positive reactions were grouped as nonatopic subjects.Atopic sensitization was observed in 22 (29%) of 76 children. At 3 weeks, the bacterial cellular fatty acid profile in fecal samples differed significantly between infants in whom atopy was and was not developing (P =.005). By using fluorescence in situ hydridization, atopic subjects had more clostridia (geometric mean [95% confidence interval]: 9.3 x 10(7) [3.8-22.9 x 10(7)] vs 3.3 x 10(7) [1.8-6.1 x 10(7)], P =.04) and tended to have fewer bifidobacteria (1.8 x 10(9) [0.4-7.6 x 10(9)] vs 6.1 x 10(9) [2.5-14.6 x 10(9)], P =.11) in their stools than nonatopic subjects, resulting in a reduced ratio of bifidobacteria to clostridia (P =.03). The differences were not detected by bacterial cultivation.Differences in the neonatal gut microflora precede the development of atopy, suggesting a crucial role of the balance of indigenous intestinal bacteria for the maturation of human immunity to a nonatopic mode." @default.
• W2000452395 created "2016-06-24" @default.
• W2000452395 creator A5048306185 @default.
• W2000452395 creator A5050767971 @default.
• W2000452395 creator A5067835507 @default.
• W2000452395 creator A5070824369 @default.
• W2000452395 creator A5071970175 @default.
• W2000452395 creator A5072093984 @default.
• W2000452395 date "2001-01-01" @default.
• W2000452395 modified "2023-10-17" @default.
• W2000452395 title "Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing" @default.
• W2000452395 cites W114544159 @default.
• W2000452395 cites W1487602178 @default.
• W2000452395 cites W1524217669 @default.
• W2000452395 cites W1549149232 @default.
• W2000452395 cites W1832474145 @default.
• W2000452395 cites W1966679064 @default.
• W2000452395 cites W1968876609 @default.
• W2000452395 cites W1983934133 @default.
• W2000452395 cites W1987107342 @default.
• W2000452395 cites W2005628478 @default.
• W2000452395 cites W2033441782 @default.
• W2000452395 cites W2034467419 @default.
• W2000452395 cites W2035831689 @default.
• W2000452395 cites W2044875902 @default.
• W2000452395 cites W2050580634 @default.
• W2000452395 cites W2053984506 @default.
• W2000452395 cites W2059378560 @default.
• W2000452395 cites W2063720477 @default.
• W2000452395 cites W2075557572 @default.
• W2000452395 cites W2087484128 @default.
• W2000452395 cites W2101398955 @default.
• W2000452395 cites W2102686780 @default.
• W2000452395 cites W2102721935 @default.
• W2000452395 cites W2111225433 @default.
• W2000452395 cites W2116329881 @default.
• W2000452395 cites W2131114862 @default.
• W2000452395 cites W2131670325 @default.
• W2000452395 cites W2131988453 @default.
• W2000452395 cites W2138253380 @default.
• W2000452395 cites W2140482528 @default.
• W2000452395 cites W2142758173 @default.
• W2000452395 cites W2151402600 @default.
• W2000452395 cites W2155525029 @default.
• W2000452395 cites W2492458801 @default.
• W2000452395 cites W313115561 @default.
• W2000452395 doi "https://doi.org/10.1067/mai.2001.111237" @default.
• W2000452395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11150002" @default.
• W2000452395 hasPublicationYear "2001" @default.
• W2000452395 type Work @default.
• W2000452395 sameAs 2000452395 @default.
• W2000452395 citedByCount "1147" @default.
• W2000452395 countsByYear W20004523952012 @default.
• W2000452395 countsByYear W20004523952013 @default.
• W2000452395 countsByYear W20004523952014 @default.
• W2000452395 countsByYear W20004523952015 @default.
• W2000452395 countsByYear W20004523952016 @default.
• W2000452395 countsByYear W20004523952017 @default.
• W2000452395 countsByYear W20004523952018 @default.
• W2000452395 countsByYear W20004523952019 @default.
• W2000452395 countsByYear W20004523952020 @default.
• W2000452395 countsByYear W20004523952021 @default.
• W2000452395 countsByYear W20004523952022 @default.
• W2000452395 countsByYear W20004523952023 @default.
• W2000452395 crossrefType "journal-article" @default.
• W2000452395 hasAuthorship W2000452395A5048306185 @default.
• W2000452395 hasAuthorship W2000452395A5050767971 @default.
• W2000452395 hasAuthorship W2000452395A5067835507 @default.
• W2000452395 hasAuthorship W2000452395A5070824369 @default.
• W2000452395 hasAuthorship W2000452395A5071970175 @default.
• W2000452395 hasAuthorship W2000452395A5072093984 @default.
• W2000452395 hasBestOaLocation W20004523951 @default.
• W2000452395 hasConcept C203014093 @default.
• W2000452395 hasConcept C207480886 @default.
• W2000452395 hasConcept C2776217527 @default.
• W2000452395 hasConcept C2777697326 @default.
• W2000452395 hasConcept C2779341262 @default.
• W2000452395 hasConcept C42407357 @default.
• W2000452395 hasConcept C61716771 @default.
• W2000452395 hasConcept C71924100 @default.
• W2000452395 hasConcept C78635009 @default.
• W2000452395 hasConcept C86803240 @default.
• W2000452395 hasConcept C8891405 @default.
• W2000452395 hasConcept C89423630 @default.
• W2000452395 hasConceptScore W2000452395C203014093 @default.
• W2000452395 hasConceptScore W2000452395C207480886 @default.
• W2000452395 hasConceptScore W2000452395C2776217527 @default.
• W2000452395 hasConceptScore W2000452395C2777697326 @default.
• W2000452395 hasConceptScore W2000452395C2779341262 @default.
• W2000452395 hasConceptScore W2000452395C42407357 @default.
• W2000452395 hasConceptScore W2000452395C61716771 @default.
• W2000452395 hasConceptScore W2000452395C71924100 @default.
• W2000452395 hasConceptScore W2000452395C78635009 @default.
• W2000452395 hasConceptScore W2000452395C86803240 @default.
• W2000452395 hasConceptScore W2000452395C8891405 @default.
• W2000452395 hasConceptScore W2000452395C89423630 @default.
• W2000452395 hasIssue "1" @default.
• W2000452395 hasLocation W20004523951 @default.

• next