FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000452494> ?p ?o ?g. }

• W2000452494 endingPage "671" @default.
• W2000452494 startingPage "665" @default.
• W2000452494 abstract "The rarity of dedifferentiated liposarcoma (DDLPS) and the lack of experimental DDLPS models limit the development of novel therapeutic strategies. Pazopanib (PAZ) is a tyrosine kinase inhibitor that is approved for the treatment of non-adipocytic advanced soft tissue sarcoma. The activity of this agent has not yet been properly explored in preclinical liposarcoma models nor in a randomized phase Ш clinical trial in this entity. The aim of the present study was to investigate whether PAZ had antitumor activity in DDLPS models in vivo.We established two patient-derived DDLPS xenograft models (UZLX-STS3 and UZLX-STS5) through implantation of tumor material from sarcoma patients in athymic nude NMRI mice. An animal model of the SW872 liposarcoma cell line was also used. To investigate the efficacy of PAZ in vivo, mice bearing tumors were treated for 2 weeks with sterile water, doxorubicin (1.2 mg/kg, intraperitoneally, twice per week), PAZ [40 mg/kg, orally (p.o.), twice per day], or PAZ plus doxorubicin (same schedules as for single treatments).Patient-derived xenografts retained the histologic and molecular features of DDLPS. PAZ significantly delayed tumor growth by decreasing proliferation and inhibited angiogenesis in all models tested. Combining the angiogenesis inhibitor with an anthracycline did not show superior efficacy.These results suggest that PAZ has potential antitumor activity in DDLPS primarily through antiangiogenic effects and therefore should be explored in clinical trials." @default.
• W2000452494 created "2016-06-24" @default.
• W2000452494 creator A5015197719 @default.
• W2000452494 creator A5020502444 @default.
• W2000452494 creator A5021550191 @default.
• W2000452494 creator A5033715270 @default.
• W2000452494 creator A5037313267 @default.
• W2000452494 creator A5042786501 @default.
• W2000452494 creator A5050142222 @default.
• W2000452494 creator A5055506828 @default.
• W2000452494 creator A5066023359 @default.
• W2000452494 creator A5071653337 @default.
• W2000452494 creator A5086102127 @default.
• W2000452494 date "2014-12-01" @default.
• W2000452494 modified "2023-10-14" @default.
• W2000452494 title "Pazopanib, a Receptor Tyrosine Kinase Inhibitor, Suppresses Tumor Growth through Angiogenesis in Dedifferentiated Liposarcoma Xenograft Models" @default.
• W2000452494 cites W1964963490 @default.
• W2000452494 cites W1965871143 @default.
• W2000452494 cites W1974228208 @default.
• W2000452494 cites W1976382591 @default.
• W2000452494 cites W1981260088 @default.
• W2000452494 cites W1982933649 @default.
• W2000452494 cites W1993570465 @default.
• W2000452494 cites W1994487360 @default.
• W2000452494 cites W2003112634 @default.
• W2000452494 cites W2006202974 @default.
• W2000452494 cites W2018153447 @default.
• W2000452494 cites W2026111799 @default.
• W2000452494 cites W2037281949 @default.
• W2000452494 cites W2057195209 @default.
• W2000452494 cites W2057509370 @default.
• W2000452494 cites W2061292442 @default.
• W2000452494 cites W2069119289 @default.
• W2000452494 cites W2076701855 @default.
• W2000452494 cites W2085096689 @default.
• W2000452494 cites W2089403275 @default.
• W2000452494 cites W2099022883 @default.
• W2000452494 cites W2101776780 @default.
• W2000452494 cites W2103626657 @default.
• W2000452494 cites W2105371674 @default.
• W2000452494 cites W2107230638 @default.
• W2000452494 cites W2109937560 @default.
• W2000452494 cites W2113991862 @default.
• W2000452494 cites W2117620802 @default.
• W2000452494 cites W2127447993 @default.
• W2000452494 cites W2129288285 @default.
• W2000452494 cites W2134433047 @default.
• W2000452494 cites W2150636063 @default.
• W2000452494 cites W2155652261 @default.
• W2000452494 cites W2155769700 @default.
• W2000452494 cites W2156902079 @default.
• W2000452494 cites W2162424705 @default.
• W2000452494 doi "https://doi.org/10.1016/j.tranon.2014.09.007" @default.
• W2000452494 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4311036" @default.
• W2000452494 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25500074" @default.
• W2000452494 hasPublicationYear "2014" @default.
• W2000452494 type Work @default.
• W2000452494 sameAs 2000452494 @default.
• W2000452494 citedByCount "36" @default.
• W2000452494 countsByYear W20004524942015 @default.
• W2000452494 countsByYear W20004524942016 @default.
• W2000452494 countsByYear W20004524942017 @default.
• W2000452494 countsByYear W20004524942018 @default.
• W2000452494 countsByYear W20004524942019 @default.
• W2000452494 countsByYear W20004524942020 @default.
• W2000452494 countsByYear W20004524942021 @default.
• W2000452494 countsByYear W20004524942022 @default.
• W2000452494 crossrefType "journal-article" @default.
• W2000452494 hasAuthorship W2000452494A5015197719 @default.
• W2000452494 hasAuthorship W2000452494A5020502444 @default.
• W2000452494 hasAuthorship W2000452494A5021550191 @default.
• W2000452494 hasAuthorship W2000452494A5033715270 @default.
• W2000452494 hasAuthorship W2000452494A5037313267 @default.
• W2000452494 hasAuthorship W2000452494A5042786501 @default.
• W2000452494 hasAuthorship W2000452494A5050142222 @default.
• W2000452494 hasAuthorship W2000452494A5055506828 @default.
• W2000452494 hasAuthorship W2000452494A5066023359 @default.
• W2000452494 hasAuthorship W2000452494A5071653337 @default.
• W2000452494 hasAuthorship W2000452494A5086102127 @default.
• W2000452494 hasBestOaLocation W20004524941 @default.
• W2000452494 hasConcept C121608353 @default.
• W2000452494 hasConcept C126322002 @default.
• W2000452494 hasConcept C142724271 @default.
• W2000452494 hasConcept C150903083 @default.
• W2000452494 hasConcept C170493617 @default.
• W2000452494 hasConcept C207001950 @default.
• W2000452494 hasConcept C2776694085 @default.
• W2000452494 hasConcept C2778256501 @default.
• W2000452494 hasConcept C2778439243 @default.
• W2000452494 hasConcept C2778629024 @default.
• W2000452494 hasConcept C2778820342 @default.
• W2000452494 hasConcept C2779490328 @default.
• W2000452494 hasConcept C2779568860 @default.
• W2000452494 hasConcept C2780394083 @default.
• W2000452494 hasConcept C2780752271 @default.
• W2000452494 hasConcept C2781303535 @default.
• W2000452494 hasConcept C42362537 @default.
• W2000452494 hasConcept C502942594 @default.

• next