FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000453793> ?p ?o ?g. }

• W2000453793 endingPage "173" @default.
• W2000453793 startingPage "165" @default.
• W2000453793 abstract "The uncoupling protein UCP1 is a member of a superfamily of homologous proteins formed by the mitochondrial metabolite transporters. Although they act in vivo as carriers, under specific experimental conditions some of these transporters have been shown to behave as channels. This dual transport operation suggests that these carriers are likely to be formed by two differentiated functional and structural domains. The kinetic model termed single binding center gated pore is well suited to understand the behaviour of these carriers. It proposes that in the protein core there must exist a hydrophilic translocation pore whose access is controlled by gates. It is highly likely that the hydrophilic channel is formed by the transmembrane alpha-helices and that loops contribute to the formation of the gates. UCP1 is regulated physiologically by fatty acids and purine nucleotides. Nucleotides maintain the proton conductance inhibited while fatty acids act as cytosolic second messengers of noradrenaline to active UCP1. Based on photoaffinity labeling and mutagenesis data, we propose a structural model for the localization of the binding site. The nucleotide enters through a gate in the cytosolic side and binds deep inside the protein. The three matrix loops contribute to the formation of a hydrophobic binding pocket that would accommodate the purine moiety. Three arginine residues (in helices II, IV, and VI) would interact with the phosphate groups. His214 and Glu190 have been involved in the pH regulation of the nucleotide binding but because they are on the cytosolic side of the protein, we propose that their state of protonation will determine the access of the nucleotide to the binding center." @default.
• W2000453793 created "2016-06-24" @default.
• W2000453793 creator A5004783644 @default.
• W2000453793 creator A5062758530 @default.
• W2000453793 creator A5087583162 @default.
• W2000453793 date "2001-09-01" @default.
• W2000453793 modified "2023-09-24" @default.
• W2000453793 title "The Mitochondrial Uncoupling Protein UCP1: A Gated Pore" @default.
• W2000453793 cites W113173875 @default.
• W2000453793 cites W1507060386 @default.
• W2000453793 cites W1519247927 @default.
• W2000453793 cites W1522261519 @default.
• W2000453793 cites W1523078511 @default.
• W2000453793 cites W1557140781 @default.
• W2000453793 cites W1562611546 @default.
• W2000453793 cites W1601518037 @default.
• W2000453793 cites W1616682748 @default.
• W2000453793 cites W1756233575 @default.
• W2000453793 cites W1883707147 @default.
• W2000453793 cites W1900866157 @default.
• W2000453793 cites W1963641364 @default.
• W2000453793 cites W1965948140 @default.
• W2000453793 cites W1970529716 @default.
• W2000453793 cites W1972240339 @default.
• W2000453793 cites W1980455487 @default.
• W2000453793 cites W1982928579 @default.
• W2000453793 cites W1987110948 @default.
• W2000453793 cites W1988756997 @default.
• W2000453793 cites W1991211417 @default.
• W2000453793 cites W1992196201 @default.
• W2000453793 cites W1996577648 @default.
• W2000453793 cites W1998854328 @default.
• W2000453793 cites W1999021477 @default.
• W2000453793 cites W1999159221 @default.
• W2000453793 cites W2005088640 @default.
• W2000453793 cites W2008172969 @default.
• W2000453793 cites W2009405449 @default.
• W2000453793 cites W2012317568 @default.
• W2000453793 cites W2014348989 @default.
• W2000453793 cites W2015536606 @default.
• W2000453793 cites W2017708912 @default.
• W2000453793 cites W2022411831 @default.
• W2000453793 cites W2022562250 @default.
• W2000453793 cites W2025091742 @default.
• W2000453793 cites W2028814041 @default.
• W2000453793 cites W2032814494 @default.
• W2000453793 cites W2033024099 @default.
• W2000453793 cites W2033669535 @default.
• W2000453793 cites W2038335563 @default.
• W2000453793 cites W2040921324 @default.
• W2000453793 cites W2047612546 @default.
• W2000453793 cites W2051516736 @default.
• W2000453793 cites W2053033635 @default.
• W2000453793 cites W2057472590 @default.
• W2000453793 cites W2061199004 @default.
• W2000453793 cites W2063944141 @default.
• W2000453793 cites W2070205534 @default.
• W2000453793 cites W2071950147 @default.
• W2000453793 cites W2073534355 @default.
• W2000453793 cites W2075559016 @default.
• W2000453793 cites W2077558263 @default.
• W2000453793 cites W2077827322 @default.
• W2000453793 cites W2078587220 @default.
• W2000453793 cites W2083618956 @default.
• W2000453793 cites W2086935995 @default.
• W2000453793 cites W2087141032 @default.
• W2000453793 cites W2092818410 @default.
• W2000453793 cites W2092823267 @default.
• W2000453793 cites W2095558833 @default.
• W2000453793 cites W2104385322 @default.
• W2000453793 cites W2109318635 @default.
• W2000453793 cites W2125427223 @default.
• W2000453793 cites W2132643262 @default.
• W2000453793 cites W2133781018 @default.
• W2000453793 cites W2136689463 @default.
• W2000453793 cites W2177482008 @default.
• W2000453793 cites W2313380666 @default.
• W2000453793 cites W2334907123 @default.
• W2000453793 cites W2336889373 @default.
• W2000453793 cites W2404274051 @default.
• W2000453793 cites W93980221 @default.
• W2000453793 cites W99927065 @default.
• W2000453793 doi "https://doi.org/10.1080/15216540152845966" @default.
• W2000453793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11798029" @default.
• W2000453793 hasPublicationYear "2001" @default.
• W2000453793 type Work @default.
• W2000453793 sameAs 2000453793 @default.
• W2000453793 citedByCount "51" @default.
• W2000453793 countsByYear W20004537932012 @default.
• W2000453793 countsByYear W20004537932013 @default.
• W2000453793 countsByYear W20004537932014 @default.
• W2000453793 countsByYear W20004537932015 @default.
• W2000453793 countsByYear W20004537932016 @default.
• W2000453793 countsByYear W20004537932017 @default.
• W2000453793 countsByYear W20004537932018 @default.
• W2000453793 countsByYear W20004537932019 @default.
• W2000453793 countsByYear W20004537932020 @default.
• W2000453793 countsByYear W20004537932021 @default.

• next