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- W2000453905 abstract "Near-u.v. photoexcited promazine and three of its derivatives are shown to induce single-strand breaks in ΦX174-DNA replicative form. The mechanisms of this DNA breakage depend upon the various photochemical properties of the promazine derivatives. Chlorpromazine is shown to act predominantly via the photodechlorination reaction both in aerobic and anaerobic conditions. The three other promazine derivatives (promazine, trifluopromazine and methoxypromazine) display two mechanisms for DNA breakage. One of them occurs through the cation radical, which is formed during near-u.v. irradiation of promazine derivatives. The second mechanism is demonstrated to act via an hydroxyl radical-dependent pathway. Acepromazine is without photoactivated action. EPR-spin-trapping studies of irradiated mixtures, containing the drugs and 5,5-dimethyl-l-pyrroline-N-oxide (as spin trap), suggest the production of Superoxide radical by photoexcited promazines. When DNA is present in the irradiation mixture, this Superoxide radical is converted into hydroxyl radical probably via a Haber Weiss-type reaction, catalysed by DNA-iron complexes." @default.
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- W2000453905 date "1984-12-01" @default.
- W2000453905 modified "2023-10-12" @default.
- W2000453905 title "Induction of breaks in deoxyribonucleic acid by photoexcited promazine derivatives" @default.
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- W2000453905 doi "https://doi.org/10.1016/0006-2952(84)90016-9" @default.
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