FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000454039> ?p ?o ?g. }

• W2000454039 endingPage "708" @default.
• W2000454039 startingPage "704" @default.
• W2000454039 abstract "AIMS To study changes in the expression of insulin-like growth factors (IGFs) and their receptors, as well as production of the IGF-I and IGF-II polypeptides, in adenocarcinoma of the colon. METHODS Malignant tissue obtained at operation was used. Total RNA was extracted and specific IGF-I and IGF-II and their receptor mRNAs were measured by a solution hybridisation RNase protection assay. IGF-I and IGF-II polypeptides were measured by specific immunoassays. RESULTS All normal tissues expressed IGF-II, IGF-I receptor, and IGF-II/mannose-6-phosphate (Man-6-P) receptor. IGF-I mRNA could not be detected but the polypeptide was present in small but equal amounts in normal and malignant tissue. IGF-II was expressed 40 times more abundantly in colonic tumours than in adjacent normal tissue and the concentration of the corresponding polypeptide was twice as high in the malignant tissue. IGF-I receptor expression was increased by a factor of 2.5 and IGF-II/Man-6-P receptor by a factor of 4. CONCLUSIONS This study confirms that in adenocarcinoma of the human colon there is increased expression of IGF-I receptor and IGF-II. Furthermore, IGF-II/Man-6-P receptor message is increased and the increase in IGF-II message is accompanied by a doubling of the IGF-II protein in the tumour tissue compared with the adjacent normal tissue. These findings suggest that the IGF-II/Man-6-P receptor may also be involved in development of adenocarcinoma of the colon. There is rapidly accumulating evidence implicating the IGF system in the development of malignancy of the large bowel." @default.
• W2000454039 created "2016-06-24" @default.
• W2000454039 creator A5005611842 @default.
• W2000454039 creator A5006265147 @default.
• W2000454039 creator A5017645952 @default.
• W2000454039 creator A5039578268 @default.
• W2000454039 creator A5041201756 @default.
• W2000454039 creator A5045298057 @default.
• W2000454039 creator A5064961143 @default.
• W2000454039 creator A5073517018 @default.
• W2000454039 creator A5088821332 @default.
• W2000454039 date "1999-05-01" @default.
• W2000454039 modified "2023-10-10" @default.
• W2000454039 title "Expression of the insulin-like growth factors and their receptors in adenocarcinoma of the colon" @default.
• W2000454039 cites W1499890190 @default.
• W2000454039 cites W1500340316 @default.
• W2000454039 cites W1515918650 @default.
• W2000454039 cites W1558473757 @default.
• W2000454039 cites W1603860993 @default.
• W2000454039 cites W168969388 @default.
• W2000454039 cites W1737917216 @default.
• W2000454039 cites W1841006979 @default.
• W2000454039 cites W1964652533 @default.
• W2000454039 cites W1986937402 @default.
• W2000454039 cites W1989210846 @default.
• W2000454039 cites W1997512958 @default.
• W2000454039 cites W2009928329 @default.
• W2000454039 cites W2011542432 @default.
• W2000454039 cites W2021520796 @default.
• W2000454039 cites W2024842732 @default.
• W2000454039 cites W2044643325 @default.
• W2000454039 cites W2055634649 @default.
• W2000454039 cites W2055854094 @default.
• W2000454039 cites W2057645543 @default.
• W2000454039 cites W2064744782 @default.
• W2000454039 cites W2077420540 @default.
• W2000454039 cites W2102123572 @default.
• W2000454039 cites W2116213773 @default.
• W2000454039 cites W2119176033 @default.
• W2000454039 cites W2119233666 @default.
• W2000454039 cites W2134812217 @default.
• W2000454039 cites W2238744128 @default.
• W2000454039 cites W2395278466 @default.
• W2000454039 cites W35099944 @default.
• W2000454039 doi "https://doi.org/10.1136/gut.44.5.704" @default.
• W2000454039 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1727486" @default.
• W2000454039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10205209" @default.
• W2000454039 hasPublicationYear "1999" @default.
• W2000454039 type Work @default.
• W2000454039 sameAs 2000454039 @default.
• W2000454039 citedByCount "139" @default.
• W2000454039 countsByYear W20004540392012 @default.
• W2000454039 countsByYear W20004540392013 @default.
• W2000454039 countsByYear W20004540392014 @default.
• W2000454039 countsByYear W20004540392015 @default.
• W2000454039 countsByYear W20004540392016 @default.
• W2000454039 countsByYear W20004540392017 @default.
• W2000454039 countsByYear W20004540392018 @default.
• W2000454039 countsByYear W20004540392019 @default.
• W2000454039 countsByYear W20004540392020 @default.
• W2000454039 countsByYear W20004540392021 @default.
• W2000454039 countsByYear W20004540392023 @default.
• W2000454039 crossrefType "journal-article" @default.
• W2000454039 hasAuthorship W2000454039A5005611842 @default.
• W2000454039 hasAuthorship W2000454039A5006265147 @default.
• W2000454039 hasAuthorship W2000454039A5017645952 @default.
• W2000454039 hasAuthorship W2000454039A5039578268 @default.
• W2000454039 hasAuthorship W2000454039A5041201756 @default.
• W2000454039 hasAuthorship W2000454039A5045298057 @default.
• W2000454039 hasAuthorship W2000454039A5064961143 @default.
• W2000454039 hasAuthorship W2000454039A5073517018 @default.
• W2000454039 hasAuthorship W2000454039A5088821332 @default.
• W2000454039 hasBestOaLocation W20004540391 @default.
• W2000454039 hasConcept C104317684 @default.
• W2000454039 hasConcept C105580179 @default.
• W2000454039 hasConcept C108190873 @default.
• W2000454039 hasConcept C121608353 @default.
• W2000454039 hasConcept C126322002 @default.
• W2000454039 hasConcept C134018914 @default.
• W2000454039 hasConcept C150194340 @default.
• W2000454039 hasConcept C170493617 @default.
• W2000454039 hasConcept C194993378 @default.
• W2000454039 hasConcept C2775960820 @default.
• W2000454039 hasConcept C2779069268 @default.
• W2000454039 hasConcept C2780689927 @default.
• W2000454039 hasConcept C2781182431 @default.
• W2000454039 hasConcept C2908605954 @default.
• W2000454039 hasConcept C2993002077 @default.
• W2000454039 hasConcept C55493867 @default.
• W2000454039 hasConcept C71924100 @default.
• W2000454039 hasConcept C86803240 @default.
• W2000454039 hasConceptScore W2000454039C104317684 @default.
• W2000454039 hasConceptScore W2000454039C105580179 @default.
• W2000454039 hasConceptScore W2000454039C108190873 @default.
• W2000454039 hasConceptScore W2000454039C121608353 @default.
• W2000454039 hasConceptScore W2000454039C126322002 @default.
• W2000454039 hasConceptScore W2000454039C134018914 @default.
• W2000454039 hasConceptScore W2000454039C150194340 @default.

• next