Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000454756> ?p ?o ?g. }
- W2000454756 endingPage "345" @default.
- W2000454756 startingPage "338" @default.
- W2000454756 abstract "The retinoic acid receptor-related orphan receptors α and γ (RORα and RORγ), are key regulators of helper T (Th)17 cell differentiation, which is involved in the innate immune system and autoimmune disorders. However, it remains unclear whether environmental chemicals, including pesticides, have agonistic and/or antagonistic activity against RORα/γ. In this study, we investigated the RORα/γ activity of several azole-type fungicides, and the effects of these fungicides on the gene expression of interleukin (IL)-17, which mediates the function of Th17 cells. In the ROR-reporter gene assays, five azole-type fungicides (imibenconazole, triflumizole, hexaconazole, tetraconazole and imazalil) suppressed RORα- and/or RORγ-mediated transcriptional activity as did benzenesulphonamide T0901317, a ROR inverse agonist and a liver X receptor (LXR) agonist. In particular, imibenconazole, triflumizole and hexaconazole showed RORγ inverse agonistic activity at concentrations of 10(-6)M. However, unlike T0901317, these fungicides failed to show any LXRα/β agonistic activity. Next, five azole-type fungicides, showing ROR inverse agonist activity, were tested on IL-17 mRNA expression in mouse T lymphoma EL4 cells treated with phorbol myristate acetate and ionomycin. The quantitative RT-PCR analysis revealed that these fungicides suppressed the expression of IL-17 mRNA without effecting RORα and RORγ mRNA levels. In addition, the inhibitory effect of imibenconazole as well as that of T0901317 was absorbed in RORα/γ-knocked down EL4 cells. Taken together, these results suggest that some azole-type fungicides inhibit IL-17 production via RORα/γ. This also provides the first evidence that environmental chemicals can act as modulators of IL-17 expression in immune cells." @default.
- W2000454756 created "2016-06-24" @default.
- W2000454756 creator A5007501845 @default.
- W2000454756 creator A5016798596 @default.
- W2000454756 creator A5045660079 @default.
- W2000454756 creator A5069280551 @default.
- W2000454756 creator A5073624633 @default.
- W2000454756 creator A5082866335 @default.
- W2000454756 creator A5085230647 @default.
- W2000454756 date "2012-03-01" @default.
- W2000454756 modified "2023-09-23" @default.
- W2000454756 title "Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ" @default.
- W2000454756 cites W1491042062 @default.
- W2000454756 cites W1968362155 @default.
- W2000454756 cites W1972815843 @default.
- W2000454756 cites W1973508918 @default.
- W2000454756 cites W1976591271 @default.
- W2000454756 cites W1987628377 @default.
- W2000454756 cites W1990814794 @default.
- W2000454756 cites W1991185289 @default.
- W2000454756 cites W1994315436 @default.
- W2000454756 cites W1996989066 @default.
- W2000454756 cites W2000366854 @default.
- W2000454756 cites W2004186675 @default.
- W2000454756 cites W2007701002 @default.
- W2000454756 cites W2010762097 @default.
- W2000454756 cites W2017724775 @default.
- W2000454756 cites W2019796661 @default.
- W2000454756 cites W2020215852 @default.
- W2000454756 cites W2024771105 @default.
- W2000454756 cites W2025226012 @default.
- W2000454756 cites W2042138395 @default.
- W2000454756 cites W2047756822 @default.
- W2000454756 cites W2054262928 @default.
- W2000454756 cites W2072859659 @default.
- W2000454756 cites W2073356061 @default.
- W2000454756 cites W2077492907 @default.
- W2000454756 cites W2078833287 @default.
- W2000454756 cites W2079071895 @default.
- W2000454756 cites W2080292301 @default.
- W2000454756 cites W2085534739 @default.
- W2000454756 cites W2089756004 @default.
- W2000454756 cites W2091451666 @default.
- W2000454756 cites W2107235439 @default.
- W2000454756 cites W2109041281 @default.
- W2000454756 cites W2118140890 @default.
- W2000454756 cites W2138442451 @default.
- W2000454756 cites W2142017607 @default.
- W2000454756 cites W2156451877 @default.
- W2000454756 cites W2168497012 @default.
- W2000454756 doi "https://doi.org/10.1016/j.taap.2012.01.011" @default.
- W2000454756 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3799977" @default.
- W2000454756 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22289359" @default.
- W2000454756 hasPublicationYear "2012" @default.
- W2000454756 type Work @default.
- W2000454756 sameAs 2000454756 @default.
- W2000454756 citedByCount "38" @default.
- W2000454756 countsByYear W20004547562012 @default.
- W2000454756 countsByYear W20004547562013 @default.
- W2000454756 countsByYear W20004547562014 @default.
- W2000454756 countsByYear W20004547562015 @default.
- W2000454756 countsByYear W20004547562016 @default.
- W2000454756 countsByYear W20004547562017 @default.
- W2000454756 countsByYear W20004547562018 @default.
- W2000454756 countsByYear W20004547562019 @default.
- W2000454756 countsByYear W20004547562020 @default.
- W2000454756 countsByYear W20004547562021 @default.
- W2000454756 countsByYear W20004547562022 @default.
- W2000454756 countsByYear W20004547562023 @default.
- W2000454756 crossrefType "journal-article" @default.
- W2000454756 hasAuthorship W2000454756A5007501845 @default.
- W2000454756 hasAuthorship W2000454756A5016798596 @default.
- W2000454756 hasAuthorship W2000454756A5045660079 @default.
- W2000454756 hasAuthorship W2000454756A5069280551 @default.
- W2000454756 hasAuthorship W2000454756A5073624633 @default.
- W2000454756 hasAuthorship W2000454756A5082866335 @default.
- W2000454756 hasAuthorship W2000454756A5085230647 @default.
- W2000454756 hasBestOaLocation W20004547562 @default.
- W2000454756 hasConcept C104317684 @default.
- W2000454756 hasConcept C167400880 @default.
- W2000454756 hasConcept C170493617 @default.
- W2000454756 hasConcept C185592680 @default.
- W2000454756 hasConcept C203014093 @default.
- W2000454756 hasConcept C2778938600 @default.
- W2000454756 hasConcept C2779161069 @default.
- W2000454756 hasConcept C2779548794 @default.
- W2000454756 hasConcept C2779727006 @default.
- W2000454756 hasConcept C2780315139 @default.
- W2000454756 hasConcept C2781121885 @default.
- W2000454756 hasConcept C55493867 @default.
- W2000454756 hasConcept C63932345 @default.
- W2000454756 hasConcept C74737994 @default.
- W2000454756 hasConcept C86339819 @default.
- W2000454756 hasConcept C86803240 @default.
- W2000454756 hasConcept C8891405 @default.
- W2000454756 hasConcept C89423630 @default.
- W2000454756 hasConcept C89951826 @default.
- W2000454756 hasConcept C98274493 @default.