Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000454853> ?p ?o ?g. }
- W2000454853 endingPage "365" @default.
- W2000454853 startingPage "355" @default.
- W2000454853 abstract "A total of 104 patients, aged 18 to 70 years, with a diagnosis of chronic idiopathic myelofibrosis (CIMF), polycythemia vera (PV), or essential thrombocythemia (ET) with marrow fibrosis were transplanted from allogeneic (56 related and 45 unrelated) or syngeneic (n = 3) donors. Busulfan (BU) or total body irradiation (TBI)-based myeloablative conditioning regimens were used in 95 patients, and a nonmyeloablative regimen of fludarabine plus TBI was used in 9 patients. The source of stem cells was bone marrow in 43 patients and peripheral blood in 61 patients. A total of 63 patients were alive at a follow-up of 1.3–15.2 years (median, 5.3 years), for an estimated 7-year actuarial survival rate of 61%. Eleven patients had recurrent/persistent disease, of whom 8 died. Nonrelapse mortality was 34% at 5 years. Patients conditioned with targeted BU (plasma levels 800–900 ng/mL) plus cyclophosphamide (tBUCY) had a higher probability of survival (68%) than other patients. Dupriez score, platelet count, patient age, and comorbidity score were statistically significantly associated with mortality in univariate models. In a multivariable regression model, use of tBUCY (P = .03), high platelet count at transplantation (P = .01 for PV/ET; P = .39 for other diagnoses), younger patient age (P = .04), and decreased comorbidity score (P = .03) remained statistically significant for improved survival. Our findings show that hematopoietic cell transplantation offers potentially curative treatment for patients with ICMF, PV, or ET." @default.
- W2000454853 created "2016-06-24" @default.
- W2000454853 creator A5007983797 @default.
- W2000454853 creator A5011099910 @default.
- W2000454853 creator A5013130893 @default.
- W2000454853 creator A5030145530 @default.
- W2000454853 creator A5035557098 @default.
- W2000454853 creator A5051266970 @default.
- W2000454853 creator A5053986124 @default.
- W2000454853 creator A5055653502 @default.
- W2000454853 creator A5056405520 @default.
- W2000454853 creator A5058845981 @default.
- W2000454853 creator A5060725545 @default.
- W2000454853 creator A5062597461 @default.
- W2000454853 creator A5070819714 @default.
- W2000454853 creator A5074629157 @default.
- W2000454853 creator A5084915025 @default.
- W2000454853 creator A5085787488 @default.
- W2000454853 creator A5088859237 @default.
- W2000454853 creator A5089494498 @default.
- W2000454853 date "2007-03-01" @default.
- W2000454853 modified "2023-10-03" @default.
- W2000454853 title "Hematopoietic Cell Transplantation as Curative Therapy for Idiopathic Myelofibrosis, Advanced Polycythemia Vera, and Essential Thrombocythemia" @default.
- W2000454853 cites W114565271 @default.
- W2000454853 cites W140365778 @default.
- W2000454853 cites W1581000033 @default.
- W2000454853 cites W1812819045 @default.
- W2000454853 cites W1910981723 @default.
- W2000454853 cites W1977086270 @default.
- W2000454853 cites W1978760468 @default.
- W2000454853 cites W1980568348 @default.
- W2000454853 cites W1981406947 @default.
- W2000454853 cites W1983344261 @default.
- W2000454853 cites W1986730299 @default.
- W2000454853 cites W1999009523 @default.
- W2000454853 cites W2000445173 @default.
- W2000454853 cites W2008952929 @default.
- W2000454853 cites W2015506962 @default.
- W2000454853 cites W2021912533 @default.
- W2000454853 cites W2032184104 @default.
- W2000454853 cites W2039956148 @default.
- W2000454853 cites W2046719918 @default.
- W2000454853 cites W2053278212 @default.
- W2000454853 cites W2057360098 @default.
- W2000454853 cites W2061119990 @default.
- W2000454853 cites W2085920715 @default.
- W2000454853 cites W2093328665 @default.
- W2000454853 cites W2118322536 @default.
- W2000454853 cites W2119160082 @default.
- W2000454853 cites W2128812336 @default.
- W2000454853 cites W2129219546 @default.
- W2000454853 cites W2136016420 @default.
- W2000454853 cites W2146910383 @default.
- W2000454853 cites W2164426492 @default.
- W2000454853 cites W2198037418 @default.
- W2000454853 cites W2247784410 @default.
- W2000454853 cites W2276362528 @default.
- W2000454853 cites W2326795317 @default.
- W2000454853 cites W2337969406 @default.
- W2000454853 cites W3114368461 @default.
- W2000454853 cites W4293241248 @default.
- W2000454853 cites W2039517358 @default.
- W2000454853 doi "https://doi.org/10.1016/j.bbmt.2006.11.004" @default.
- W2000454853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17317589" @default.
- W2000454853 hasPublicationYear "2007" @default.
- W2000454853 type Work @default.
- W2000454853 sameAs 2000454853 @default.
- W2000454853 citedByCount "171" @default.
- W2000454853 countsByYear W20004548532012 @default.
- W2000454853 countsByYear W20004548532013 @default.
- W2000454853 countsByYear W20004548532014 @default.
- W2000454853 countsByYear W20004548532015 @default.
- W2000454853 countsByYear W20004548532016 @default.
- W2000454853 countsByYear W20004548532017 @default.
- W2000454853 countsByYear W20004548532018 @default.
- W2000454853 countsByYear W20004548532019 @default.
- W2000454853 countsByYear W20004548532020 @default.
- W2000454853 countsByYear W20004548532021 @default.
- W2000454853 countsByYear W20004548532022 @default.
- W2000454853 countsByYear W20004548532023 @default.
- W2000454853 crossrefType "journal-article" @default.
- W2000454853 hasAuthorship W2000454853A5007983797 @default.
- W2000454853 hasAuthorship W2000454853A5011099910 @default.
- W2000454853 hasAuthorship W2000454853A5013130893 @default.
- W2000454853 hasAuthorship W2000454853A5030145530 @default.
- W2000454853 hasAuthorship W2000454853A5035557098 @default.
- W2000454853 hasAuthorship W2000454853A5051266970 @default.
- W2000454853 hasAuthorship W2000454853A5053986124 @default.
- W2000454853 hasAuthorship W2000454853A5055653502 @default.
- W2000454853 hasAuthorship W2000454853A5056405520 @default.
- W2000454853 hasAuthorship W2000454853A5058845981 @default.
- W2000454853 hasAuthorship W2000454853A5060725545 @default.
- W2000454853 hasAuthorship W2000454853A5062597461 @default.
- W2000454853 hasAuthorship W2000454853A5070819714 @default.
- W2000454853 hasAuthorship W2000454853A5074629157 @default.
- W2000454853 hasAuthorship W2000454853A5084915025 @default.
- W2000454853 hasAuthorship W2000454853A5085787488 @default.
- W2000454853 hasAuthorship W2000454853A5088859237 @default.