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• W2000455311 abstract "Ganciclovir (GCV) prophylaxis or pre-emptive therapy significantly reduce the rate of cytomegalovirus (CMV) disease and viremia, but increase the potential for emergence of ganciclovir-resistant CMV strains. The inhibitor concentration at 50% (IC(50)) of GCV from 156 CMV isolates from 59 renal or heart transplant recipients was calculated by means of a rapid phenotypic susceptibility assay. Twenty-seven strains were from 14 patients undergoing GCV therapy. The IC(50) was higher in patients under the prophylaxis regimen. One CMV strain, from a heart transplant recipient, became GCV-resistant after 1 month of therapy (IC(50)=13.7 micromol/l). These data, together with clinical and virological markers, suggested that a switch to foscarnet was necessary, and good evolution was observed. Thus, assay of CMV susceptibility to GCV could be helpful in clinical management." @default.
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• W2000455311 date "2002-11-01" @default.
• W2000455311 modified "2023-09-25" @default.
• W2000455311 title "Assay of cytomegalovirus susceptibility to ganciclovir in renal and heart transplant recipients" @default.
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• W2000455311 doi "https://doi.org/10.1007/s00147-002-0453-6" @default.
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