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- W2000456697 abstract "Historical controls are frequently used in the clinical evaluation of a new therapy. Sample size tables are needed for such non-randomized studies since these determinations can differ markedly from the widely published sample size estimates appropriate for randomized comparative studies. A comprehensive array of sample size tables are therefore provided to aid investigators in the planning of non-randomized comparative trials. The equations and tables presented in this paper reflect the extent to which the number of patients required to receive the new therapy depends on the number of historical controls selected for comparison. Guidelines for the use of historical controls and the pooling of several historical-control groups are discussed." @default.
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- W2000456697 title "Sample size considerations for non-randomized comparative studies" @default.
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- W2000456697 doi "https://doi.org/10.1016/0021-9681(80)90017-x" @default.
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