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- W2000458273 abstract "Analysis of (sHLA-I) antigens in a large number of HIV-positive subjects found a significant increase of their level, but did not detect any change in their molecular profile. Monitoring at yearly intervals for four years of the sHLA-I antigen level in 14 HIV-positive subjects with a normal sHLA-I antigen level at study entry showed a significant correlation between progressive increase of sHLA-I antigen level and disease progression. Furthermore, a Kaplan-Meier plot of the frequency of development of AIDS in 34 patients whose cases were followed for 7 years showed that sHLA-I antigen level is a strong predictor of progression to AIDS. Its predictive value is comparable to that of serum β2-μ level, greater than that of serum neopterin, and lower than that of CD4 + T-cell percentage. The predictive value of sHLA-I antigen level in combination with serum β2-μ level, neopterin level, or CD4 + T-cell percentage is greater than that of each individual variable. These results suggest that measurement of the sHLA-I antigen level may provide useful prognostic information in HIV-positive subjects. Human Immunology 40, 259–266 (1994)" @default.
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- W2000458273 date "1994-08-01" @default.
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- W2000458273 title "Increased level of serum HLA class I antigens in HIV infection correlation with disease progression" @default.
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- W2000458273 doi "https://doi.org/10.1016/0198-8859(94)90025-6" @default.
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