Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000459405> ?p ?o ?g. }
- W2000459405 endingPage "2079" @default.
- W2000459405 startingPage "2071" @default.
- W2000459405 abstract "Pituitary adenylate cyclase-activating polypeptide (PACAP) is a bioactive peptide isolated from ovine hypothalamus. It is transiently expressed in preovulatory follicles and positively affects several parameters correlated with the ovulatory process. It has also been shown to be expressed in the interstitial tissue around primordial and preantral follicles. The aim of the present study was to investigate whether PACAP influences preantral follicle growth and differentiation. Mouse preantral follicles were cultured for 5 d in the presence of FSH and increasing concentrations of PACAP or vasoactive intestinal polypeptide (VIP) (10−12 to 10−7m). In the presence of FSH, follicles increased in diameter and formed an antrum. At the concentrations tested, neither PACAP alone nor VIP alone had any effect on follicle development, but the addition of either peptide to FSH-stimulated follicles caused a dose-dependent inhibition of follicle growth, antrum formation, granulosa cell proliferation, and estradiol production. The effect of PACAP on follicle growth and antrum formation was directly correlated with the length of stimulation and was reversible. Although exposure of follicles to 10−7m PACAP and VIP did not affect oocyte growth, it severely impaired completion of meiotic maturation in oocytes isolated from the follicles and cultured for 17 h in medium alone. The cyclic production of PACAP by preovulatory follicles during the estrous cycle in adult rats and its induction by LH in the rat and mouse ovary suggest that this peptide may play a role in the local regulation of preantral follicle growth." @default.
- W2000459405 created "2016-06-24" @default.
- W2000459405 creator A5024017760 @default.
- W2000459405 creator A5028973222 @default.
- W2000459405 creator A5051562923 @default.
- W2000459405 creator A5055904797 @default.
- W2000459405 creator A5073252089 @default.
- W2000459405 date "2004-04-01" @default.
- W2000459405 modified "2023-09-28" @default.
- W2000459405 title "Effect of Pituitary Adenylate Cyclase-Activating Polypeptide and Vasoactive Intestinal Polypeptide on Mouse Preantral Follicle Development in Vitro" @default.
- W2000459405 cites W1518913349 @default.
- W2000459405 cites W1775749144 @default.
- W2000459405 cites W1933460820 @default.
- W2000459405 cites W1964322366 @default.
- W2000459405 cites W1964492032 @default.
- W2000459405 cites W1966346366 @default.
- W2000459405 cites W1966361056 @default.
- W2000459405 cites W1967032043 @default.
- W2000459405 cites W1967308454 @default.
- W2000459405 cites W1971932969 @default.
- W2000459405 cites W1977342735 @default.
- W2000459405 cites W1977962650 @default.
- W2000459405 cites W1979067492 @default.
- W2000459405 cites W1981423842 @default.
- W2000459405 cites W1987161479 @default.
- W2000459405 cites W1995790354 @default.
- W2000459405 cites W1997975361 @default.
- W2000459405 cites W2009715203 @default.
- W2000459405 cites W2009971819 @default.
- W2000459405 cites W2017398123 @default.
- W2000459405 cites W2020851589 @default.
- W2000459405 cites W2023850590 @default.
- W2000459405 cites W2023980655 @default.
- W2000459405 cites W2024697593 @default.
- W2000459405 cites W2027244127 @default.
- W2000459405 cites W2029835781 @default.
- W2000459405 cites W2033650768 @default.
- W2000459405 cites W2048668952 @default.
- W2000459405 cites W2050275256 @default.
- W2000459405 cites W2050647858 @default.
- W2000459405 cites W2054382126 @default.
- W2000459405 cites W2056797992 @default.
- W2000459405 cites W2059835695 @default.
- W2000459405 cites W2065440994 @default.
- W2000459405 cites W2071317058 @default.
- W2000459405 cites W2073511974 @default.
- W2000459405 cites W2073551875 @default.
- W2000459405 cites W2074657811 @default.
- W2000459405 cites W2077018960 @default.
- W2000459405 cites W2094437995 @default.
- W2000459405 cites W2113621749 @default.
- W2000459405 cites W2124261971 @default.
- W2000459405 cites W2130250478 @default.
- W2000459405 cites W2135758786 @default.
- W2000459405 cites W2145613913 @default.
- W2000459405 cites W2156837840 @default.
- W2000459405 cites W2160088320 @default.
- W2000459405 cites W4294216491 @default.
- W2000459405 doi "https://doi.org/10.1210/en.2003-1004" @default.
- W2000459405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14701671" @default.
- W2000459405 hasPublicationYear "2004" @default.
- W2000459405 type Work @default.
- W2000459405 sameAs 2000459405 @default.
- W2000459405 citedByCount "36" @default.
- W2000459405 countsByYear W20004594052012 @default.
- W2000459405 countsByYear W20004594052013 @default.
- W2000459405 countsByYear W20004594052014 @default.
- W2000459405 countsByYear W20004594052015 @default.
- W2000459405 countsByYear W20004594052016 @default.
- W2000459405 countsByYear W20004594052018 @default.
- W2000459405 countsByYear W20004594052019 @default.
- W2000459405 countsByYear W20004594052020 @default.
- W2000459405 crossrefType "journal-article" @default.
- W2000459405 hasAuthorship W2000459405A5024017760 @default.
- W2000459405 hasAuthorship W2000459405A5028973222 @default.
- W2000459405 hasAuthorship W2000459405A5051562923 @default.
- W2000459405 hasAuthorship W2000459405A5055904797 @default.
- W2000459405 hasAuthorship W2000459405A5073252089 @default.
- W2000459405 hasBestOaLocation W20004594051 @default.
- W2000459405 hasConcept C102570824 @default.
- W2000459405 hasConcept C118303440 @default.
- W2000459405 hasConcept C126322002 @default.
- W2000459405 hasConcept C131253125 @default.
- W2000459405 hasConcept C134018914 @default.
- W2000459405 hasConcept C142773365 @default.
- W2000459405 hasConcept C170493617 @default.
- W2000459405 hasConcept C180526460 @default.
- W2000459405 hasConcept C185592680 @default.
- W2000459405 hasConcept C196843134 @default.
- W2000459405 hasConcept C1998276 @default.
- W2000459405 hasConcept C24998067 @default.
- W2000459405 hasConcept C2777216303 @default.
- W2000459405 hasConcept C2778324911 @default.
- W2000459405 hasConcept C2779422922 @default.
- W2000459405 hasConcept C2779496938 @default.
- W2000459405 hasConcept C2780069284 @default.
- W2000459405 hasConcept C2780536345 @default.
- W2000459405 hasConcept C5512455 @default.