FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000459868> ?p ?o ?g. }

• W2000459868 endingPage "1650" @default.
• W2000459868 startingPage "1638" @default.
• W2000459868 abstract "In an attempt to devise new antimicrobial treatments for biofilm infections, the bacterial cell-cell communication system termed quorum sensing has emerged as an attractive target. It has proven possible to intercept the communication system by synthetic non-native ligands and thereby lower the pathogenesis and antibiotic tolerance of a bacterial biofilm. To identify the structural elements important for antagonistic or agonistic activity against the Pseudomonas aeruginosa LasR protein, we report the synthesis and screening of new triazole-containing mimics of natural N-acyl homoserine lactones. A series of azide- and alkyne-containing homoserine lactone building blocks was used to prepare an expanded set of 123 homoserine lactone analogues through a combination of solution- and solid-phase synthesis methods. The resulting compounds were subjected to cell-based quorum sensing screening assays, thereby revealing several bioactive compounds, including 13 compounds with antagonistic activity and 9 compounds with agonistic activity." @default.
• W2000459868 created "2016-06-24" @default.
• W2000459868 creator A5004988031 @default.
• W2000459868 creator A5031476041 @default.
• W2000459868 creator A5043122653 @default.
• W2000459868 creator A5052592791 @default.
• W2000459868 creator A5062399163 @default.
• W2000459868 creator A5074060263 @default.
• W2000459868 creator A5082362836 @default.
• W2000459868 creator A5082377308 @default.
• W2000459868 creator A5084065671 @default.
• W2000459868 creator A5086066741 @default.
• W2000459868 date "2015-04-01" @default.
• W2000459868 modified "2023-10-01" @default.
• W2000459868 title "Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa" @default.
• W2000459868 cites W12119413 @default.
• W2000459868 cites W1502461125 @default.
• W2000459868 cites W1943112463 @default.
• W2000459868 cites W1965538842 @default.
• W2000459868 cites W1968652549 @default.
• W2000459868 cites W1971306414 @default.
• W2000459868 cites W1975151193 @default.
• W2000459868 cites W1977105094 @default.
• W2000459868 cites W1983115764 @default.
• W2000459868 cites W1993177760 @default.
• W2000459868 cites W2005330098 @default.
• W2000459868 cites W2011681082 @default.
• W2000459868 cites W2043960936 @default.
• W2000459868 cites W2049602321 @default.
• W2000459868 cites W2061320336 @default.
• W2000459868 cites W2066687131 @default.
• W2000459868 cites W2069101181 @default.
• W2000459868 cites W2070596988 @default.
• W2000459868 cites W2074779228 @default.
• W2000459868 cites W2080094366 @default.
• W2000459868 cites W2084007578 @default.
• W2000459868 cites W2084475131 @default.
• W2000459868 cites W2085222365 @default.
• W2000459868 cites W2096653634 @default.
• W2000459868 cites W2119410664 @default.
• W2000459868 cites W2126922170 @default.
• W2000459868 cites W2136294927 @default.
• W2000459868 cites W2136847512 @default.
• W2000459868 cites W2137215017 @default.
• W2000459868 cites W2138776000 @default.
• W2000459868 cites W2145662716 @default.
• W2000459868 cites W2146292204 @default.
• W2000459868 cites W2151399020 @default.
• W2000459868 cites W2152683145 @default.
• W2000459868 cites W2154447238 @default.
• W2000459868 cites W2162427999 @default.
• W2000459868 cites W2171527366 @default.
• W2000459868 cites W2321995885 @default.
• W2000459868 cites W2949931220 @default.
• W2000459868 cites W4256634851 @default.
• W2000459868 doi "https://doi.org/10.1016/j.bmc.2015.01.038" @default.
• W2000459868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25716005" @default.
• W2000459868 hasPublicationYear "2015" @default.
• W2000459868 type Work @default.
• W2000459868 sameAs 2000459868 @default.
• W2000459868 citedByCount "31" @default.
• W2000459868 countsByYear W20004598682015 @default.
• W2000459868 countsByYear W20004598682016 @default.
• W2000459868 countsByYear W20004598682017 @default.
• W2000459868 countsByYear W20004598682018 @default.
• W2000459868 countsByYear W20004598682019 @default.
• W2000459868 countsByYear W20004598682020 @default.
• W2000459868 countsByYear W20004598682021 @default.
• W2000459868 countsByYear W20004598682023 @default.
• W2000459868 crossrefType "journal-article" @default.
• W2000459868 hasAuthorship W2000459868A5004988031 @default.
• W2000459868 hasAuthorship W2000459868A5031476041 @default.
• W2000459868 hasAuthorship W2000459868A5043122653 @default.
• W2000459868 hasAuthorship W2000459868A5052592791 @default.
• W2000459868 hasAuthorship W2000459868A5062399163 @default.
• W2000459868 hasAuthorship W2000459868A5074060263 @default.
• W2000459868 hasAuthorship W2000459868A5082362836 @default.
• W2000459868 hasAuthorship W2000459868A5082377308 @default.
• W2000459868 hasAuthorship W2000459868A5084065671 @default.
• W2000459868 hasAuthorship W2000459868A5086066741 @default.
• W2000459868 hasConcept C104317684 @default.
• W2000459868 hasConcept C118687296 @default.
• W2000459868 hasConcept C178790620 @default.
• W2000459868 hasConcept C185592680 @default.
• W2000459868 hasConcept C21951064 @default.
• W2000459868 hasConcept C2776612806 @default.
• W2000459868 hasConcept C2777637488 @default.
• W2000459868 hasConcept C2779840497 @default.
• W2000459868 hasConcept C4937899 @default.
• W2000459868 hasConcept C523546767 @default.
• W2000459868 hasConcept C54355233 @default.
• W2000459868 hasConcept C55493867 @default.
• W2000459868 hasConcept C58123911 @default.
• W2000459868 hasConcept C60987743 @default.
• W2000459868 hasConcept C86803240 @default.
• W2000459868 hasConcept C89423630 @default.
• W2000459868 hasConceptScore W2000459868C104317684 @default.
• W2000459868 hasConceptScore W2000459868C118687296 @default.

• next