Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000462205> ?p ?o ?g. }
- W2000462205 endingPage "322" @default.
- W2000462205 startingPage "312" @default.
- W2000462205 abstract "The thioredoxins are ubiquitous proteins containing a conserved -Trp-Cys-Gly-Pro-Cys-Lys- redox catalytic site. Mammalian thioredoxin family members include thioredoxin-1 (Trx1), mitochondrial thioredoxin-2 (Trx2), and a larger thioredoxin-like protein, p32TrxL. Thioredoxin is reduced by NADPH and thioredoxin reductase and, in turn reduces oxidized cysteine groups on proteins. When thioredoxin levels are elevated there is increased cell growth and resistance to the normal mechanism of programmed cell death. An increase in thioredoxin levels seen in many human primary cancers compared to normal tissue appears to contribute to increased cancer cell growth and resistance to chemotherapy. Mechanisms by which thioredoxin increases cell growth include an increased supply of reducing equivalents for DNA synthesis, activation of transcription factors that regulate cell growth, and an increase in the sensitivity of cells to other cytokines and growth factors. The mechanisms for the inhibition of apoptosis by thioredoxin are just now being elucidated. Because of its role in stimulating cancer cell growth and as an inhibitor of apoptosis, thioredoxin offers a target for the development of drugs to treat and prevent cancer." @default.
- W2000462205 created "2016-06-24" @default.
- W2000462205 creator A5011101496 @default.
- W2000462205 creator A5011412582 @default.
- W2000462205 creator A5085173566 @default.
- W2000462205 date "2000-08-01" @default.
- W2000462205 modified "2023-09-27" @default.
- W2000462205 title "The role of the redox protein thioredoxin in cell growth and cancer" @default.
- W2000462205 cites W1497318066 @default.
- W2000462205 cites W1501442799 @default.
- W2000462205 cites W1516144786 @default.
- W2000462205 cites W1516245997 @default.
- W2000462205 cites W1517639918 @default.
- W2000462205 cites W1536099429 @default.
- W2000462205 cites W1550909330 @default.
- W2000462205 cites W1565745037 @default.
- W2000462205 cites W1567647424 @default.
- W2000462205 cites W1574486032 @default.
- W2000462205 cites W1577403013 @default.
- W2000462205 cites W1578330187 @default.
- W2000462205 cites W1586722842 @default.
- W2000462205 cites W1595838029 @default.
- W2000462205 cites W1767331507 @default.
- W2000462205 cites W181261420 @default.
- W2000462205 cites W1842535138 @default.
- W2000462205 cites W1963557394 @default.
- W2000462205 cites W1963738481 @default.
- W2000462205 cites W1966527292 @default.
- W2000462205 cites W1969268163 @default.
- W2000462205 cites W1969779044 @default.
- W2000462205 cites W1972241251 @default.
- W2000462205 cites W1972352578 @default.
- W2000462205 cites W1973328612 @default.
- W2000462205 cites W1977810724 @default.
- W2000462205 cites W1978029697 @default.
- W2000462205 cites W1978690847 @default.
- W2000462205 cites W1982145118 @default.
- W2000462205 cites W1983397667 @default.
- W2000462205 cites W1985448020 @default.
- W2000462205 cites W1985916621 @default.
- W2000462205 cites W1987682836 @default.
- W2000462205 cites W1991387227 @default.
- W2000462205 cites W1994840063 @default.
- W2000462205 cites W1994915896 @default.
- W2000462205 cites W1995775226 @default.
- W2000462205 cites W2001912697 @default.
- W2000462205 cites W2002593979 @default.
- W2000462205 cites W2002598577 @default.
- W2000462205 cites W2002931771 @default.
- W2000462205 cites W2003344121 @default.
- W2000462205 cites W2003607850 @default.
- W2000462205 cites W2004493326 @default.
- W2000462205 cites W2009757343 @default.
- W2000462205 cites W2012673501 @default.
- W2000462205 cites W2014365431 @default.
- W2000462205 cites W2015837249 @default.
- W2000462205 cites W2019358729 @default.
- W2000462205 cites W2021528178 @default.
- W2000462205 cites W2028640163 @default.
- W2000462205 cites W2033243838 @default.
- W2000462205 cites W2034260628 @default.
- W2000462205 cites W2034580062 @default.
- W2000462205 cites W2037313086 @default.
- W2000462205 cites W2039679198 @default.
- W2000462205 cites W2042404113 @default.
- W2000462205 cites W2044404386 @default.
- W2000462205 cites W2045899523 @default.
- W2000462205 cites W2046987575 @default.
- W2000462205 cites W2048272805 @default.
- W2000462205 cites W2053291096 @default.
- W2000462205 cites W2059222508 @default.
- W2000462205 cites W2064280448 @default.
- W2000462205 cites W2065404736 @default.
- W2000462205 cites W2066415215 @default.
- W2000462205 cites W2068001141 @default.
- W2000462205 cites W2069725516 @default.
- W2000462205 cites W2069867696 @default.
- W2000462205 cites W2070693959 @default.
- W2000462205 cites W2071592594 @default.
- W2000462205 cites W2072963191 @default.
- W2000462205 cites W2073880421 @default.
- W2000462205 cites W2078794355 @default.
- W2000462205 cites W2079062297 @default.
- W2000462205 cites W2084028198 @default.
- W2000462205 cites W2085605930 @default.
- W2000462205 cites W2085976933 @default.
- W2000462205 cites W2091770096 @default.
- W2000462205 cites W2092443356 @default.
- W2000462205 cites W2095585565 @default.
- W2000462205 cites W2100841967 @default.
- W2000462205 cites W2120705173 @default.
- W2000462205 cites W2121096033 @default.
- W2000462205 cites W2132863919 @default.
- W2000462205 cites W2141273782 @default.
- W2000462205 cites W2148597566 @default.
- W2000462205 cites W2148937254 @default.
- W2000462205 cites W2172271037 @default.
- W2000462205 cites W2236241003 @default.