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• W2000464994 abstract "Indomethacin is widely used to treat inflammatory and prevent adverse events which are frequently accrues in biotherapy. In phase I clinical trial of recombinant human lymphotoxin α (rhLTα), indomethacin was premedicated to alleviate chill and fever. However, it is unknown whether indomethacin influences the therapeutic efficacy of rhLTα. In this study we found that pre-treatment with low dose of indomethacin enhanced the cytotoxicity of rhLTα and/or cisplatin/adriamycin on human tumor cells. Further investigation demonstrated that indomethacin dose-dependently suppressed the activation of nuclear factor-kappa B (NF-κB) by inhibiting phosphorylation and degradation of IκB-α. In addition, indomethacin decreased the expression of NF-κB-regulated gene products involved in rhLTα-induced anti-apoptosis (XIAP, cFLIP and cIAP-1), which may explain its sensitization of tumor cells to rhLTα and/or cisplatin/adriamycin." @default.
• W2000464994 created "2016-06-24" @default.
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• W2000464994 date "2007-09-01" @default.
• W2000464994 modified "2023-09-25" @default.
• W2000464994 title "Indomethacin enhances the cytotoxicity of recombinant human lymphotoxin α on tumor cells by suppressing NF-κB signaling" @default.
• W2000464994 doi "https://doi.org/10.4161/cbt.6.9.4559" @default.
• W2000464994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17873517" @default.
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