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• W2000465029 abstract "CRISPR/Cas systems are bacterial RNA-guided endonuclease machineries that target foreign nucleic acids. Recently, we demonstrated that the Cas protein Cas9 controls gene expression and virulence in Francisella novicida by altering the stability of the mRNA for an immunostimulatory bacterial lipoprotein (BLP). Genomic analyses, however, revealed that Francisella species with increased virulence harbor degenerated CRISPR/Cas systems. We hypothesize that CRISPR/Cas degeneration removed a barrier against genome alterations, which resulted in enhanced virulence. Importantly, the BLP locus was also lost; likely a necessary adaptation in the absence of Cas9-mediated repression. CRISPR/Cas systems likely play regulatory roles in numerous bacteria, and these data suggest additional genomic changes may be required to maintain fitness after CRISPR/Cas loss in such bacteria, having important evolutionary implications." @default.
• W2000465029 created "2016-06-24" @default.
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• W2000465029 date "2013-10-01" @default.
• W2000465029 modified "2023-09-25" @default.
• W2000465029 title "Degeneration of a CRISPR/Cas system and its regulatory target during the evolution of a pathogen" @default.
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• W2000465029 doi "https://doi.org/10.4161/rna.26423" @default.
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