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- W2000466154 abstract "In the main, intracavitary radium therapy may be defined as the application of radium to the surface of a lesion occurring in any hollow place or space. Not only is it the oldest form of radium therapy of carcinoma of the uterine cervix but it also is a conservative method. Many improvements and refinements have made it most effective. Our experience with this method at the Mayo Clinic covers a period of thirty years. During that time, the technic employed has been rather constant, which permits the widest possible interpretation of the variable factors inherent in the patient and the disease. The history, bimanual palpation, inspection and sounding of the genital tract, especially in the predominating Stage III lesion, are essential for diagnosis and treatment. A general physical examination and the required laboratory tests, ineluding removal of tissue from the primary lesion for microscopic study, are absolutely essential from the standpoint of good management. A knowledge of pathology and physiology will sharpen the interest of the therapeutic radiologist. As a rule, constant vigilance by the physician and patient will be an important element in obtaining a good immediate and late result. The standard platinum tube containing 50 mg. of radium sulfate (element) is used; the walls of the tube are 1 mm. thick. The applicator may contain one or more tubes. When distance is employed, it is maintained with 2 mm. or 1 cm. of Para rubber. The following factors are approximate for treatment of the average Stage III lesion. The time of the application may vary from three to twenty-four hours; the dose, therefore, ranges from 300 to 2,400 milligram hours. The interval between applications is one to seven days. The total time consumed may be ten to twenty-one days. The treatment area is divided into zones, and the dose in milligram hours applied to each zone is as follows: to the vaginal zone 2,100, to the proximal cervical zone 1,400, to the distal cervical zone 1,400, and to the intrauterine zone 2,000 to 2,400. The method requires hospitalization only for the day of the treatment. The time that the patient has to spend in the hospital is from eight to ten days. No general anesthetic is used. A dose of 1/6 grain (0.01 gm.) of morphine sulfate may be administered hypodermically before the treatment. Barbiturates are used sparingly. All other drugs are given by the physician on the medical hospital. service. In the past few years, the field has been dusted with a sulfonamide drug at the same time that radium therapy is applied. All applications of radium are made with the patient in the knee-chest position. With gentle unilateral separation of the labia, air is admitted to the vagina, which permits a type of endoscopic examination. The endoscope consists of a Sims' speculum and a direct electric lamp with a suitable handle. The vagina becomes a distended hollow organ and permits:" @default.
- W2000466154 created "2016-06-24" @default.
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- W2000466154 date "1947-10-01" @default.
- W2000466154 modified "2023-09-25" @default.
- W2000466154 title "Intracavitary Radium Therapy for Carcinoma of the Uterine Cervix" @default.
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- W2000466154 doi "https://doi.org/10.1148/49.4.406" @default.
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