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- W2000469371 endingPage "265" @default.
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- W2000469371 abstract "The ERBB or EGF receptor (EGFR) proto-oncogene family, which consists of four structurally-related transmembrane receptors (i.e., EGFR, ErbB2, ErbB3, and ErbB4), plays an etiological role in the molecular pathogenesis of cancer and is a key therapeutic target in many types of cancer, including ovarian cancer. These ErbB/EGF receptor tyrosine kinases play important physiologic roles in cell proliferation, survival, adhesion, motility, invasion, and angiogenesis. It is, therefore, not surprising that gene amplification, genetic mutation, and altered transcription/translation result in aberrant ErbB/EGF receptor expression and/or signal transduction, contributing to the development of malignant transformation. Clinically, the diagnostic, prognostic, and theragnostic significance of any single ErbB receptor and/or ErbB ligand is controversial, but generally, ErbB receptor overexpression has been correlated with poor prognosis and decreased therapeutic responsiveness in ovarian cancer patients. Thus, anticancer agents targeting ErbB/EGF receptors hold great promise for personalized cancer treatment. Yet, challenges remain in designing prospective clinical trials to assess the clinical utility of ErbB receptors and their ligands to diagnose cancer; to predict progression-free and overall survival, therapeutic responsiveness, and disease recurrence; and to monitor treatment responsiveness. Here, we review the tissue expression and serum biomarker studies that have evaluated the diagnostic, prognostic, and theragnostic utility of ErbB/EGF receptors, their circulating soluble isoforms (sEGFR/sErbBs), and their cognate ligands in ovarian cancer patients." @default.
- W2000469371 created "2016-06-24" @default.
- W2000469371 creator A5031116230 @default.
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- W2000469371 creator A5071698177 @default.
- W2000469371 creator A5077344494 @default.
- W2000469371 date "2008-04-01" @default.
- W2000469371 modified "2023-10-17" @default.
- W2000469371 title "Clinical implications of the ErbB/epidermal growth factor (EGF) receptor family and its ligands in ovarian cancer" @default.
- W2000469371 cites W1488828742 @default.
- W2000469371 cites W1491740602 @default.
- W2000469371 cites W1500256341 @default.
- W2000469371 cites W1501383613 @default.
- W2000469371 cites W1550092936 @default.
- W2000469371 cites W1553976553 @default.
- W2000469371 cites W1562926557 @default.
- W2000469371 cites W1574013273 @default.
- W2000469371 cites W1579739997 @default.
- W2000469371 cites W1595839746 @default.
- W2000469371 cites W1596261235 @default.
- W2000469371 cites W1597819373 @default.
- W2000469371 cites W1607351680 @default.
- W2000469371 cites W1810521495 @default.
- W2000469371 cites W1895740739 @default.
- W2000469371 cites W1950601528 @default.
- W2000469371 cites W1963804483 @default.
- W2000469371 cites W1964493811 @default.
- W2000469371 cites W1965355187 @default.
- W2000469371 cites W1966425687 @default.
- W2000469371 cites W1966502030 @default.
- W2000469371 cites W1966996035 @default.
- W2000469371 cites W1967274438 @default.
- W2000469371 cites W1967957985 @default.
- W2000469371 cites W1969499061 @default.
- W2000469371 cites W1970446746 @default.
- W2000469371 cites W1970631761 @default.
- W2000469371 cites W1971133173 @default.
- W2000469371 cites W1972005224 @default.
- W2000469371 cites W1972085092 @default.
- W2000469371 cites W1972878967 @default.
- W2000469371 cites W1973188134 @default.
- W2000469371 cites W1973323865 @default.
- W2000469371 cites W1974170604 @default.
- W2000469371 cites W1975138180 @default.
- W2000469371 cites W1975813995 @default.
- W2000469371 cites W1976131754 @default.
- W2000469371 cites W1976555242 @default.
- W2000469371 cites W1976748749 @default.
- W2000469371 cites W1977125175 @default.
- W2000469371 cites W1977270903 @default.
- W2000469371 cites W1978082129 @default.
- W2000469371 cites W1978648231 @default.
- W2000469371 cites W1980561538 @default.
- W2000469371 cites W1981108516 @default.
- W2000469371 cites W1981141514 @default.
- W2000469371 cites W1982958415 @default.
- W2000469371 cites W1983616496 @default.
- W2000469371 cites W1985804074 @default.
- W2000469371 cites W1987657791 @default.
- W2000469371 cites W1988371171 @default.
- W2000469371 cites W1988642198 @default.
- W2000469371 cites W1989051196 @default.
- W2000469371 cites W1989069744 @default.
- W2000469371 cites W1989558595 @default.
- W2000469371 cites W1990375473 @default.
- W2000469371 cites W1991899196 @default.
- W2000469371 cites W1992139451 @default.
- W2000469371 cites W1992161286 @default.
- W2000469371 cites W1992221703 @default.
- W2000469371 cites W1994185611 @default.
- W2000469371 cites W1994341785 @default.
- W2000469371 cites W1994727820 @default.
- W2000469371 cites W1995242599 @default.
- W2000469371 cites W1995337883 @default.
- W2000469371 cites W1996045429 @default.
- W2000469371 cites W1996571855 @default.
- W2000469371 cites W1996721080 @default.
- W2000469371 cites W1998106693 @default.
- W2000469371 cites W1998722304 @default.
- W2000469371 cites W1999243658 @default.
- W2000469371 cites W2000292756 @default.
- W2000469371 cites W2000295610 @default.
- W2000469371 cites W2000630926 @default.
- W2000469371 cites W2000776349 @default.
- W2000469371 cites W2000898067 @default.
- W2000469371 cites W2000957125 @default.
- W2000469371 cites W2001124278 @default.
- W2000469371 cites W2002129133 @default.
- W2000469371 cites W2003592884 @default.
- W2000469371 cites W2003792276 @default.
- W2000469371 cites W2004317205 @default.
- W2000469371 cites W2005025634 @default.
- W2000469371 cites W2005274511 @default.
- W2000469371 cites W2006087610 @default.
- W2000469371 cites W2006621710 @default.
- W2000469371 cites W2007256480 @default.
- W2000469371 cites W2007649418 @default.
- W2000469371 cites W2009838252 @default.