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- W2000470168 abstract "ABSTRACT In Escherichia coli , there are 32 open reading frames (ORFs) that are assumed to be response regulator genes of two-component signal transduction systems on the basis of sequence similarities. We cloned all of these 32 ORFs into a multicopy expression vector and investigated whether or not they confer drug resistance via control of drug resistance determinants. Fifteen of these ORFs, i.e., baeR , citB , cpxR , evgA , fimZ , kdpE , narL , narP , ompR , rcsB , rstA , torR , yedW , yehT , and dcuR , conferred increased single- or multidrug resistance. Two-thirds of them conferred deoxycholate resistance. Five of them, i.e., evgA , baeR , ompR, cpxR , and rcsB , modulated the expression of several drug exporter genes. The drug resistance mediated by evgA , baeR , and cpxR could be assigned to drug exporters by using drug exporter gene knockout strains." @default.
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- W2000470168 date "2003-03-15" @default.
- W2000470168 modified "2023-09-30" @default.
- W2000470168 title "Comprehensive Studies of Drug Resistance Mediated by Overexpression of Response Regulators of Two-Component Signal Transduction Systems in <i>Escherichia coli</i>" @default.
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- W2000470168 doi "https://doi.org/10.1128/jb.185.6.1851-1856.2003" @default.
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