Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000470557> ?p ?o ?g. }
- W2000470557 endingPage "277" @default.
- W2000470557 startingPage "268" @default.
- W2000470557 abstract "The multitubulin hypothesis holds that each tubulin isotype serves a unique role with respect to microtubule function. Here we investigate the role of the α-tubulin subunit <i>Tuba1a</i> in adult hippocampal neurogenesis and the formation of the dentate gyrus. Employing birth date labelling and immunohistological markers, we show that mice harbouring an S140G mutation in <i>Tuba1a</i> present with normal neurogenic potential, but that this neurogenesis is often ectopic. Morphological analysis of the dentate gyrus in adulthood revealed a disorganised subgranular zone and a dispersed granule cell layer. We have shown that these anatomical abnormalities are due to defective migration of prospero-homeobox-1-positive neurons and T-box-brain-2-positive progenitors during development. Such migratory defects may also be responsible for the cytoarchitectural defects observed in the dentate gyrus of patients with mutations in <i>TUBA1A.</i>" @default.
- W2000470557 created "2016-06-24" @default.
- W2000470557 creator A5009746068 @default.
- W2000470557 creator A5011108322 @default.
- W2000470557 creator A5043794130 @default.
- W2000470557 creator A5050807379 @default.
- W2000470557 creator A5062455516 @default.
- W2000470557 creator A5079320372 @default.
- W2000470557 creator A5087984403 @default.
- W2000470557 creator A5090230747 @default.
- W2000470557 date "2010-01-01" @default.
- W2000470557 modified "2023-10-06" @default.
- W2000470557 title "The Role of <i>Tuba1a </i>in Adult Hippocampal Neurogenesis and the Formation of the Dentate Gyrus" @default.
- W2000470557 cites W1497673044 @default.
- W2000470557 cites W1580665995 @default.
- W2000470557 cites W1852889371 @default.
- W2000470557 cites W1913492258 @default.
- W2000470557 cites W1966609926 @default.
- W2000470557 cites W1979612418 @default.
- W2000470557 cites W1991336907 @default.
- W2000470557 cites W1994345197 @default.
- W2000470557 cites W2006068720 @default.
- W2000470557 cites W2006751067 @default.
- W2000470557 cites W2017513475 @default.
- W2000470557 cites W2030598357 @default.
- W2000470557 cites W2035177674 @default.
- W2000470557 cites W2041241261 @default.
- W2000470557 cites W2045227929 @default.
- W2000470557 cites W2046448747 @default.
- W2000470557 cites W2050938473 @default.
- W2000470557 cites W2054200572 @default.
- W2000470557 cites W2057624404 @default.
- W2000470557 cites W2065920939 @default.
- W2000470557 cites W2079961456 @default.
- W2000470557 cites W2083845804 @default.
- W2000470557 cites W2089394861 @default.
- W2000470557 cites W2092385088 @default.
- W2000470557 cites W2096252835 @default.
- W2000470557 cites W2096701179 @default.
- W2000470557 cites W2106204967 @default.
- W2000470557 cites W2108461283 @default.
- W2000470557 cites W2129146561 @default.
- W2000470557 cites W2145884075 @default.
- W2000470557 cites W2148751856 @default.
- W2000470557 cites W2149695265 @default.
- W2000470557 cites W2150682032 @default.
- W2000470557 cites W2163901200 @default.
- W2000470557 cites W2260866709 @default.
- W2000470557 cites W46174504 @default.
- W2000470557 doi "https://doi.org/10.1159/000319663" @default.
- W2000470557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21041996" @default.
- W2000470557 hasPublicationYear "2010" @default.
- W2000470557 type Work @default.
- W2000470557 sameAs 2000470557 @default.
- W2000470557 citedByCount "19" @default.
- W2000470557 countsByYear W20004705572012 @default.
- W2000470557 countsByYear W20004705572013 @default.
- W2000470557 countsByYear W20004705572014 @default.
- W2000470557 countsByYear W20004705572015 @default.
- W2000470557 countsByYear W20004705572016 @default.
- W2000470557 countsByYear W20004705572017 @default.
- W2000470557 countsByYear W20004705572018 @default.
- W2000470557 countsByYear W20004705572020 @default.
- W2000470557 countsByYear W20004705572022 @default.
- W2000470557 countsByYear W20004705572023 @default.
- W2000470557 crossrefType "journal-article" @default.
- W2000470557 hasAuthorship W2000470557A5009746068 @default.
- W2000470557 hasAuthorship W2000470557A5011108322 @default.
- W2000470557 hasAuthorship W2000470557A5043794130 @default.
- W2000470557 hasAuthorship W2000470557A5050807379 @default.
- W2000470557 hasAuthorship W2000470557A5062455516 @default.
- W2000470557 hasAuthorship W2000470557A5079320372 @default.
- W2000470557 hasAuthorship W2000470557A5087984403 @default.
- W2000470557 hasAuthorship W2000470557A5090230747 @default.
- W2000470557 hasBestOaLocation W20004705571 @default.
- W2000470557 hasConcept C136834591 @default.
- W2000470557 hasConcept C148762608 @default.
- W2000470557 hasConcept C169760540 @default.
- W2000470557 hasConcept C2776464000 @default.
- W2000470557 hasConcept C2777542384 @default.
- W2000470557 hasConcept C2778888523 @default.
- W2000470557 hasConcept C2781161787 @default.
- W2000470557 hasConcept C2781176699 @default.
- W2000470557 hasConcept C28328180 @default.
- W2000470557 hasConcept C4746552 @default.
- W2000470557 hasConcept C86803240 @default.
- W2000470557 hasConcept C95444343 @default.
- W2000470557 hasConceptScore W2000470557C136834591 @default.
- W2000470557 hasConceptScore W2000470557C148762608 @default.
- W2000470557 hasConceptScore W2000470557C169760540 @default.
- W2000470557 hasConceptScore W2000470557C2776464000 @default.
- W2000470557 hasConceptScore W2000470557C2777542384 @default.
- W2000470557 hasConceptScore W2000470557C2778888523 @default.
- W2000470557 hasConceptScore W2000470557C2781161787 @default.
- W2000470557 hasConceptScore W2000470557C2781176699 @default.
- W2000470557 hasConceptScore W2000470557C28328180 @default.
- W2000470557 hasConceptScore W2000470557C4746552 @default.
- W2000470557 hasConceptScore W2000470557C86803240 @default.