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- W2000470801 abstract "Tick-borne encephalitis (TBE) is a central nervous system (CNS) disease caused by the neurotropic, positive-sense RNA virus, tick-borne encephalitis virus (TBEV). A possible association between predisposition to TBE in a Russian population and two polymorphisms, a 32 bp deletion in the coding region of the chemokine receptor CCR5 gene and the rs3775291 single nucleotide polymorphism (SNP) (G/A, Leu412Phe) in exon 4 of the toll-like receptor TLR3 gene, was investigated. The genotypic and allelic frequencies of these polymorphisms were analyzed in 137 non-immunized TBE patients with different clinical manifestations, including fever (35), meningitis (62), and severe CNS disease (40), as well as in a control population (269 randomly selected Novosibirsk citizens). The frequencies of the TLR3 G allele and G/G homozygotes were significantly higher among the patients with TBE compared with the control group (P = 0.029 and 0.037, respectively), especially among patients with severe disease (P = 0.018 and 0.017, respectively). These results indicate that the G allele (within the G/G homozygous genotype) of the TLR3 rs3775291 SNP is associated with predisposition to TBE in the Russian population." @default.
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- W2000470801 date "2012-11-01" @default.
- W2000470801 modified "2023-09-24" @default.
- W2000470801 title "Isolated meningomyeloradiculitis following infection with tick borne encephalitis virus" @default.
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- W2000470801 doi "https://doi.org/10.1016/j.clineuro.2012.02.047" @default.
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