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• W2000470913 abstract "Abstract: Saturable and specific binding sites for 5-[3H]hydroxytryptamine (5-HT, serotonin) characterized by a KD of 3.5–4.5 nM were detected in the chick embryo brain and were shown to develop linearly as a function of age, weight, and protein content. Saturation and displacement studies using unlabeled 5-HT as the displacing ligand suggested a single population of binding sites. However, displacement studies using 5-methoxytryptamine, lysergic acid diethylamide (LSD), 2-bromo-lysergic acid diethylamide (BOL), methysergide, and spiperone as competing ligands suggested the existence of subclasses of [3H]5-HT binding sites because the Hill coefficients were less than unity. When compared with the reported [3H]5-HT binding sites (5-HT1) in the rat forebrain, the IC50 values of the competing ligands were similar. However, the Hill coefficients for LSD and methysergide were less than unity which suggested that the [3H]5-HT binding sites in the chick embryo brain may be more similar to those found in rat spinal cord than rat forebrain. To study [3H]5-HT binding site regulation and development, various serotonergic compounds were injected into the chorioallantoic fluid of the eggs at different times during embryonic development. Multiple pretreatments with d,l-5-hydroxytryptophan, 5-HT, or BOL were found to have no significant effects on either the affinity (KD) or number (Bmax) of specific [3H]5-HT binding sites. Multiple pretreatments with p-chlorophenylalanine were found to increase the Bmax of specific [3H]5-HT binding by 23% (p < 0.01) whereas multiple pretreatments with LSD were found to decrease the Bmax of specific binding by 45% (p < 0.01). Neither of these pretreatments affected KD values which indicated that only the number of specific [3H]5-HT binding sites was altered. Evidence was presented suggesting that these effects were probably not due to excess endogenous 5-HT or LSD remaining in the tissue preparation. The overall evidence indicated that the chick embryo brain may have a functioning serotonergic system and that the chick embryo may be an ideal system for the study of [3H]5-HT binding site regulation and development." @default.
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• W2000470913 date "1985-02-01" @default.
• W2000470913 modified "2023-09-26" @default.
• W2000470913 title "Influence on 5-[3H]Hydroxytryptamine Binding Site Development in Chick Embryo by Serotonergic Compounds" @default.
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• W2000470913 doi "https://doi.org/10.1111/j.1471-4159.1985.tb05447.x" @default.
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