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• W2000471385 abstract "Various approaches have been developed to improve efficacy of DNA vaccination, such as the use of plasmid expressing cytokine as a molecular adjuvant. In this study, we investigated whether co-inoculation of a construct expressing either IL-6 or TNF-α as the molecular adjuvant with FMDV DNA vaccine, pcD-VP1, can increase immune responses. Compared to the group immunized with pcD-VP1 alone, the co-inoculation with either molecular adjuvant induced a higher ratio of IgG2a/IgG1, higher levels of expression of IFN-γ in CD4+ and CD8+ T cells, IL-4 in CD4+ T cells, and in vivo antigen-specific cytotoxic response. Both adjuvants induced maturation of dendritic cells, suggesting a correlation between the initiating innate response and subsequent activating adaptive immune responses. Together, the results demonstrate that IL-6 and TNF-α used as molecular adjuvants can enhance the antigen-specific cell-mediated responses elicited by VP1 DNA vaccine." @default.
• W2000471385 created "2016-06-24" @default.
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• W2000471385 date "2008-09-01" @default.
• W2000471385 modified "2023-10-10" @default.
• W2000471385 title "The effects of IL-6 and TNF-α as molecular adjuvants on immune responses to FMDV and maturation of dendritic cells by DNA vaccination" @default.
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• W2000471385 doi "https://doi.org/10.1016/j.vaccine.2008.03.089" @default.
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