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- W2000471711 abstract "Extensive technical advances in the past decade have substantially expanded quantitative proteomics in cardiovascular research. This has great promise for elucidating the mechanisms of cardiovascular diseases and the discovery of cardiac biomarkers used for diagnosis and treatment evaluation. Global and targeted proteomics are the two major avenues of quantitative proteomics. While global approaches enable unbiased discovery of altered proteins via relative quantification at the proteome level, targeted techniques provide higher sensitivity and accuracy, and are capable of multiplexed absolute quantification in numerous clinical/biological samples. While promising, technical challenges need to be overcome to enable full utilization of these techniques in cardiovascular medicine. Here, we discuss recent advances in quantitative proteomics and summarize applications in cardiovascular research with an emphasis on biomarker discovery and elucidating molecular mechanisms of disease. We propose the integration of global and targeted strategies as a high-throughput pipeline for cardiovascular proteomics. Targeted approaches enable rapid, extensive validation of biomarker candidates discovered by global proteomics. These approaches provide a promising alternative to immunoassays and other low-throughput means currently used for limited validation." @default.
- W2000471711 created "2016-06-24" @default.
- W2000471711 creator A5006852480 @default.
- W2000471711 creator A5058617556 @default.
- W2000471711 creator A5063759058 @default.
- W2000471711 creator A5063990319 @default.
- W2000471711 date "2014-07-14" @default.
- W2000471711 modified "2023-10-05" @default.
- W2000471711 title "Quantitative proteomics in cardiovascular research: Global and targeted strategies" @default.
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