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- W2000471897 abstract "Cytoplasmic dynein is the major minus-end-directed microtubule motor protein in interphase cells. In addition to its well-established roles in vesicular transport and chromosome dynamics, cytoplasmic dynein also associates with the cell cortex. From this site, it appears to pull on the cytoplasmic microtubule network, influencing mitotic spindle orientation, nuclear position and other aspects of cell polarity and organization. Recent evidence indicates that the cell has the remarkable ability to calculate is geometric center, and, with the help of dynein, to position the centrosome at this central site. Here, we outline models to account for this behavior. Cytoplasmic dynein is the major minus-end-directed microtubule motor protein in interphase cells. In addition to its well-established roles in vesicular transport and chromosome dynamics, cytoplasmic dynein also associates with the cell cortex. From this site, it appears to pull on the cytoplasmic microtubule network, influencing mitotic spindle orientation, nuclear position and other aspects of cell polarity and organization. Recent evidence indicates that the cell has the remarkable ability to calculate is geometric center, and, with the help of dynein, to position the centrosome at this central site. Here, we outline models to account for this behavior." @default.
- W2000471897 created "2016-06-24" @default.
- W2000471897 creator A5059014378 @default.
- W2000471897 creator A5089071903 @default.
- W2000471897 date "2005-06-01" @default.
- W2000471897 modified "2023-09-25" @default.
- W2000471897 title "How dynein helps the cell find its center: a servomechanical model" @default.
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- W2000471897 doi "https://doi.org/10.1016/j.tcb.2005.04.005" @default.
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