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• W2000472286 abstract "The serotoninergic (5-HT) system regulates neuronal activity in broad brain regions, and appears to be particularly important for modulating behavioral and physiological functions such as mood, emotion, sleep and appetite. Central 5-HT deregulation may be involved in many neuropsychological disorders, which include substance abuse and addiction. Previous studies suggest that genetic polymorphisms in some 5-HT receptor genes may relate to heroin dependency. Here we examined potential association between heroin dependence and four single nucleotide polymorphisms (SNPs) of 5-HT receptors (A-1438G and T102C of HTR(2A), and G861C and A1180G of HTR(1B)) in a cohort of Han Chinese. Participants included 303 heroin-dependent subjects who were recruited into the Methadone Maintenance Treatment (MMT) Program in the Xi'an Mental Health Center, and 300 healthy controls. The resulting data yielded a significantly higher frequency of the HTR(1B) G allele with G861C among the heroin-dependent subjects relative to controls (p=0.001 after Bonferroni correction). Further genotype and clinical phenotype correlation study of the G861C carriers showed that the amount of heroin self-injection was higher in patients with the GG genotype relative to CC and CG genotypes (p<0.01). These findings point to a role for HTR(1B) polymorphism in heroin dependence among Han Chinese, and may be informative for future genetic or neurobiological studies on heroin dependence." @default.
• W2000472286 created "2016-06-24" @default.
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• W2000472286 date "2011-09-01" @default.
• W2000472286 modified "2023-10-12" @default.
• W2000472286 title "Polymorphism G861C of 5-HT receptor subtype 1B is associated with heroin dependence in Han Chinese" @default.
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• W2000472286 doi "https://doi.org/10.1016/j.bbrc.2011.07.114" @default.
• W2000472286 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21839728" @default.
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