Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000473065> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2000473065 abstract "Nasopharyngeal Carcinoma (NPC) is highly associated with EBV infection and lymphocytes infiltration, which contribute to form the NPC microenvironment. To better understand the NPC microenvironment, we conducted PCR array using pooled cDNA mixtures from 5 NPC tissues and their counterpart non-tumor tissues to profile inflammation-associated gene expression. We found that the Th1/Th2 related cytokines were down regulated in NPC tissues. This result was verified by Real-time quantitative PCR using 13 pairs of NPC samples and non-tumor tissues. The result of IHC staining of NPC tissues with T helper cell marker CD4 also showed decreased infiltration of T helper cells. Lower level of Th1/Th2 related cytokines were also detected in NPC serum compared to paired non-tumor serum. Osteopontin (SPP1), a glycophosphoprotein, playing roles in inflammation, bone formation, and tumor progression and metastasis, was over expressed in 67% (8/12) of NPC samples compared with non-tumor tissues. IHC staining of SPP1 in NPC tissues also showed up-regulation of SPP1 in either NPC cells or lymphocytes. To study the effect of SPP1 on T helper cells population, we cultured PBMC by adding SPP1 protein at the concentration from 0 to 100 ng/ml into the culture medium, followed by Flow Cytometry analysis. We found that Low-dose SPP1 protein stimulated T helper cell proliferation, which could be inhibited by SPP1 at high dose. Our data indicated that the over-expression of SPP1 by NPC cells might contribute to tumor immunosuppression in NPC microenvironment, thus promote cancer progression. Citation Format: Jinna Chen. The role of SPP1 in NPC microenvironment. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4262. doi:10.1158/1538-7445.AM2013-4262" @default.
- W2000473065 created "2016-06-24" @default.
- W2000473065 creator A5044300684 @default.
- W2000473065 date "2013-04-15" @default.
- W2000473065 modified "2023-09-30" @default.
- W2000473065 title "Abstract 4262: The role of SPP1 in NPC microenvironment." @default.
- W2000473065 doi "https://doi.org/10.1158/1538-7445.am2013-4262" @default.
- W2000473065 hasPublicationYear "2013" @default.
- W2000473065 type Work @default.
- W2000473065 sameAs 2000473065 @default.
- W2000473065 citedByCount "0" @default.
- W2000473065 crossrefType "proceedings-article" @default.
- W2000473065 hasAuthorship W2000473065A5044300684 @default.
- W2000473065 hasConcept C121608353 @default.
- W2000473065 hasConcept C126322002 @default.
- W2000473065 hasConcept C142724271 @default.
- W2000473065 hasConcept C167672396 @default.
- W2000473065 hasConcept C203014093 @default.
- W2000473065 hasConcept C2776107976 @default.
- W2000473065 hasConcept C2778326572 @default.
- W2000473065 hasConcept C2778997737 @default.
- W2000473065 hasConcept C2779256057 @default.
- W2000473065 hasConcept C2908647359 @default.
- W2000473065 hasConcept C502942594 @default.
- W2000473065 hasConcept C509974204 @default.
- W2000473065 hasConcept C54355233 @default.
- W2000473065 hasConcept C553184892 @default.
- W2000473065 hasConcept C71924100 @default.
- W2000473065 hasConcept C86803240 @default.
- W2000473065 hasConcept C8891405 @default.
- W2000473065 hasConcept C99454951 @default.
- W2000473065 hasConceptScore W2000473065C121608353 @default.
- W2000473065 hasConceptScore W2000473065C126322002 @default.
- W2000473065 hasConceptScore W2000473065C142724271 @default.
- W2000473065 hasConceptScore W2000473065C167672396 @default.
- W2000473065 hasConceptScore W2000473065C203014093 @default.
- W2000473065 hasConceptScore W2000473065C2776107976 @default.
- W2000473065 hasConceptScore W2000473065C2778326572 @default.
- W2000473065 hasConceptScore W2000473065C2778997737 @default.
- W2000473065 hasConceptScore W2000473065C2779256057 @default.
- W2000473065 hasConceptScore W2000473065C2908647359 @default.
- W2000473065 hasConceptScore W2000473065C502942594 @default.
- W2000473065 hasConceptScore W2000473065C509974204 @default.
- W2000473065 hasConceptScore W2000473065C54355233 @default.
- W2000473065 hasConceptScore W2000473065C553184892 @default.
- W2000473065 hasConceptScore W2000473065C71924100 @default.
- W2000473065 hasConceptScore W2000473065C86803240 @default.
- W2000473065 hasConceptScore W2000473065C8891405 @default.
- W2000473065 hasConceptScore W2000473065C99454951 @default.
- W2000473065 hasLocation W20004730651 @default.
- W2000473065 hasOpenAccess W2000473065 @default.
- W2000473065 hasPrimaryLocation W20004730651 @default.
- W2000473065 hasRelatedWork W1817373903 @default.
- W2000473065 hasRelatedWork W1971336947 @default.
- W2000473065 hasRelatedWork W2096640712 @default.
- W2000473065 hasRelatedWork W2116555294 @default.
- W2000473065 hasRelatedWork W2128844816 @default.
- W2000473065 hasRelatedWork W2157307235 @default.
- W2000473065 hasRelatedWork W2350520511 @default.
- W2000473065 hasRelatedWork W2355996975 @default.
- W2000473065 hasRelatedWork W2374514977 @default.
- W2000473065 hasRelatedWork W2379963633 @default.
- W2000473065 hasRelatedWork W2384172471 @default.
- W2000473065 hasRelatedWork W2396283712 @default.
- W2000473065 hasRelatedWork W2422076701 @default.
- W2000473065 hasRelatedWork W2472412159 @default.
- W2000473065 hasRelatedWork W2514951287 @default.
- W2000473065 hasRelatedWork W2890991181 @default.
- W2000473065 hasRelatedWork W2970572787 @default.
- W2000473065 hasRelatedWork W3016533670 @default.
- W2000473065 hasRelatedWork W3084191668 @default.
- W2000473065 hasRelatedWork W3088507815 @default.
- W2000473065 isParatext "false" @default.
- W2000473065 isRetracted "false" @default.
- W2000473065 magId "2000473065" @default.
- W2000473065 workType "article" @default.