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- W2000473509 abstract "A glucuronide-based prodrug of paclitaxel (taxol®) has been synthesized for use in antibody-directed enzyme prodrug therapy (ADEPT). This three-component prodrug was obtained by coupling a glucuronyl derivative of N-methylamino 4-nitrophenol (10) to the 2′-hydroxy group of the side-chain of paclitaxel through an aromatic carbamate. Once deprotected, prodrug 2 was shown to be relatively stable in human serum, and to be significantly less cytotoxic (IC50 = 65 μM and 90 nM, respectively) than the parent drug. As expected, compound 2 efficiently releases taxol in the presence of β-glucuronidase." @default.
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- W2000473509 date "2001-05-10" @default.
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- W2000473509 title "Cancer Chemotherapy: A Paclitaxel Prodrug for ADEPT (Antibody‐Directed Enzyme Prodrug Therapy)" @default.
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- W2000473509 doi "https://doi.org/10.1002/1099-0690(200106)2001:11<2129::aid-ejoc2129>3.0.co;2-#" @default.
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