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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000473810> ?p ?o ?g. }

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• W2000473810 abstract "Hit to lead optimization of (5R)-5-hexyl-3-phenyl-1,3-oxazolidin-2-one as a positive allosteric modulator of mGluR2 is described. Improvements in potency and metabolic stability were achieved through SAR on both ends of the oxazolidinone. An optimized lead compound was found to be brain penetrant and active in a rat ketamine-induced hyperlocomotion model for antipsychotic activity." @default.
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• W2000473810 date "2010-05-01" @default.
• W2000473810 modified "2023-10-18" @default.
• W2000473810 title "3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts" @default.
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• W2000473810 doi "https://doi.org/10.1016/j.bmcl.2010.03.089" @default.
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