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- W2000474566 abstract "This is the second in a series of reports that define the mode of action of spinosyns, a novel class of naturally derived insecticidal macrocyclic lactones. The concentration dependence of central nervous system (CNS) stimulation was determined using ganglia isolated from cockroaches, house fly larvae, and tobacco hornworm larvae. The tobacco hornworm nervous system was most sensitive, with a steep dose-response relation and an ED50of 5 nM for spinosyn A. The response of the housefly CNS was comparable, showing no clear effect at 3 nM and near-maximal stimulation at 10 nM spinosyn A. The cockroach CNS also displayed a steep dose-response relation, with a threshold of 10 nM and an EC50of 32 nM. That the nerve cords of cockroaches are exposed to comparable levels of spinosyn A during poisoning was established by comparison of the concentration of spinosyn A taken up by cockroach nerve cords during exposurein vivo,in cockroaches treated with a threshold dose, with that in isolated nerve cords equilibrated with a solution of spinosyn A in saline. A saline concentration of 21 nM was estimated to give the same nerve cord concentration as found at the threshold dose for prostration. We can conclude that during poisoning, spinosyn A reaches a concentration inside the insect that is sufficient to directly excite the central nervous system." @default.
- W2000474566 created "2016-06-24" @default.
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- W2000474566 date "1996-01-01" @default.
- W2000474566 modified "2023-10-18" @default.
- W2000474566 title "In Memoriam: Dr. Walter Carl Dauterman(1932–1995)" @default.
- W2000474566 doi "https://doi.org/10.1006/pest.1996.0002" @default.
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