FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000474866> ?p ?o ?g. }

• W2000474866 endingPage "E47" @default.
• W2000474866 startingPage "E41" @default.
• W2000474866 abstract "The effects of chronic angiotensin-converting enzyme (ACE) inhibition on intrinsic myocardial contractility of the failing myocardium have been poorly documented. In the present study, inotropy, lusitropy, and economy of force generation were studied in vitro in papillary muscles from cardiomyopathic Syrian hamster (CSH) under early perindopril therapy, i.e., therapy begun at a stage when experimental heart failure was not yet observed. One-month-old CSH from the dilated strain Bio 53.58 were randomly treated over a 5-month period with either the ACE inhibitor perindopril 1 mg/kg/day (n = 11) or placebo (n = 11), and 7 age-matched controls were given placebo. Compared with control, placebo had a lower maximum shortening velocity (Vmax) (p < 0.01) and normalized total force (p < 0.05), and a lower curvature of the force-velocity relationship (p < 0.01). It has been shown that the higher the value of the curvature, the better the myothermal economy of force generation. Compared with placebo, perindopril had a 68% inhibition of plasma ACE activity and a greater Vmax (p < 0.05), whereas total force/mm2 was similar. This resulted in a lesser decrease of the curvature compared to control (p < 0.05). Placebo had a decreased peak lengthening velocity and rate of force decline. However, compared to control, no intrinsic abnormalities of the relaxation phase were observed in either placebo or perindopril when relaxation parameters were corrected for the lower systolic performance.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2000474866 created "2016-06-24" @default.
• W2000474866 creator A5012391695 @default.
• W2000474866 creator A5057820956 @default.
• W2000474866 creator A5077552401 @default.
• W2000474866 creator A5079794318 @default.
• W2000474866 creator A5090112487 @default.
• W2000474866 creator A5063737413 @default.
• W2000474866 date "1993-06-01" @default.
• W2000474866 modified "2023-09-26" @default.
• W2000474866 title "Myocardial effects of early therapy with perindopril during experimental cardiomyopathy" @default.
• W2000474866 cites W120943192 @default.
• W2000474866 cites W140343470 @default.
• W2000474866 cites W1963698855 @default.
• W2000474866 cites W1964523159 @default.
• W2000474866 cites W1977487371 @default.
• W2000474866 cites W2000883721 @default.
• W2000474866 cites W2002899223 @default.
• W2000474866 cites W2003918511 @default.
• W2000474866 cites W2011603125 @default.
• W2000474866 cites W2026798725 @default.
• W2000474866 cites W2028504454 @default.
• W2000474866 cites W2042437462 @default.
• W2000474866 cites W2051010843 @default.
• W2000474866 cites W2053960435 @default.
• W2000474866 cites W2060000070 @default.
• W2000474866 cites W2063451261 @default.
• W2000474866 cites W2066050658 @default.
• W2000474866 cites W2081723298 @default.
• W2000474866 cites W2085485254 @default.
• W2000474866 cites W2086061329 @default.
• W2000474866 cites W2101674674 @default.
• W2000474866 cites W2112009691 @default.
• W2000474866 cites W2127917887 @default.
• W2000474866 cites W2131534168 @default.
• W2000474866 cites W2132161051 @default.
• W2000474866 cites W2132205005 @default.
• W2000474866 cites W2142247745 @default.
• W2000474866 cites W2166169771 @default.
• W2000474866 cites W2170506074 @default.
• W2000474866 cites W2171083892 @default.
• W2000474866 cites W2204401894 @default.
• W2000474866 cites W2249179847 @default.
• W2000474866 cites W2338262993 @default.
• W2000474866 cites W2403252940 @default.
• W2000474866 cites W2406108662 @default.
• W2000474866 cites W2409380395 @default.
• W2000474866 cites W2416737278 @default.
• W2000474866 cites W2418011851 @default.
• W2000474866 cites W2423738454 @default.
• W2000474866 doi "https://doi.org/10.1016/0002-9149(93)90952-9" @default.
• W2000474866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8328367" @default.
• W2000474866 hasPublicationYear "1993" @default.
• W2000474866 type Work @default.
• W2000474866 sameAs 2000474866 @default.
• W2000474866 citedByCount "6" @default.
• W2000474866 crossrefType "journal-article" @default.
• W2000474866 hasAuthorship W2000474866A5012391695 @default.
• W2000474866 hasAuthorship W2000474866A5057820956 @default.
• W2000474866 hasAuthorship W2000474866A5063737413 @default.
• W2000474866 hasAuthorship W2000474866A5077552401 @default.
• W2000474866 hasAuthorship W2000474866A5079794318 @default.
• W2000474866 hasAuthorship W2000474866A5090112487 @default.
• W2000474866 hasConcept C126322002 @default.
• W2000474866 hasConcept C134018914 @default.
• W2000474866 hasConcept C142724271 @default.
• W2000474866 hasConcept C164705383 @default.
• W2000474866 hasConcept C204787440 @default.
• W2000474866 hasConcept C27016395 @default.
• W2000474866 hasConcept C27081682 @default.
• W2000474866 hasConcept C2778198053 @default.
• W2000474866 hasConcept C2779200603 @default.
• W2000474866 hasConcept C39133596 @default.
• W2000474866 hasConcept C57900726 @default.
• W2000474866 hasConcept C68923441 @default.
• W2000474866 hasConcept C71924100 @default.
• W2000474866 hasConcept C84393581 @default.
• W2000474866 hasConceptScore W2000474866C126322002 @default.
• W2000474866 hasConceptScore W2000474866C134018914 @default.
• W2000474866 hasConceptScore W2000474866C142724271 @default.
• W2000474866 hasConceptScore W2000474866C164705383 @default.
• W2000474866 hasConceptScore W2000474866C204787440 @default.
• W2000474866 hasConceptScore W2000474866C27016395 @default.
• W2000474866 hasConceptScore W2000474866C27081682 @default.
• W2000474866 hasConceptScore W2000474866C2778198053 @default.
• W2000474866 hasConceptScore W2000474866C2779200603 @default.
• W2000474866 hasConceptScore W2000474866C39133596 @default.
• W2000474866 hasConceptScore W2000474866C57900726 @default.
• W2000474866 hasConceptScore W2000474866C68923441 @default.
• W2000474866 hasConceptScore W2000474866C71924100 @default.
• W2000474866 hasConceptScore W2000474866C84393581 @default.
• W2000474866 hasIssue "17" @default.
• W2000474866 hasLocation W20004748661 @default.
• W2000474866 hasLocation W20004748662 @default.
• W2000474866 hasOpenAccess W2000474866 @default.
• W2000474866 hasPrimaryLocation W20004748661 @default.
• W2000474866 hasRelatedWork W1514902666 @default.
• W2000474866 hasRelatedWork W2012347043 @default.

• next