Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000475291> ?p ?o ?g. }
- W2000475291 endingPage "505" @default.
- W2000475291 startingPage "497" @default.
- W2000475291 abstract "Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are commonly prescribed because of their therapeutic and preventive effects on cardiovascular diseases. Even though they have been occasionally reported to have antitumour activity, it is unknown whether statins have anti-angiogenic effect in human colorectal cancer (CRC).A total of 11 human CRC cell lines were used to test the effects of bevacizumab, statins, and bevacizumab plus statins on human umbilical vein endothelial cell (HUVEC) viability and invasion in vitro. To determine the molecular mechanism of statins as anti-angiogenic agents, we performed an angiogenesis antibody array and proteomics analysis and confirmed the results using immunoblot assay, HUVEC invasion rescue assay, and siRNA assay. The antitumoural effects of bevacizumab and statins were evaluated in xenograft models.A conventional dose of statins (simvastatin 0.2 μM, lovastatin 0.4 μM, atorvastatin 0.1 μM, and pravastatin 0.4 μM) in combination with bevacizumab directly reduced the cell viability, migration, invasion, and tube formation of HUVECs. The culture media of the CRC cells treated with bevacizumab or statins were also found to inhibit HUVEC invasion by suppressing angiogenic mediators, such as angiopoietin2, binding immunoglobulin protein (BiP), and Hsp90α. The combined treatment with bevacizumab and simvastatin significantly reduced the growth and metastases of xenograft tumours compared with treatment with bevacizumab alone.The addition of simvastatin at a dose used in patients with cardiovascular diseases (40-80 mg once daily) may potentiate the anti-angiogenic effects of bevacizumab on CRC by suppressing angiopoietin2, BiP, and Hsp90α in cancer cells. A clinical trial of simvastatin in combination with bevacizumab in patients with CRC is needed." @default.
- W2000475291 created "2016-06-24" @default.
- W2000475291 creator A5021945651 @default.
- W2000475291 creator A5025758897 @default.
- W2000475291 creator A5040103448 @default.
- W2000475291 creator A5065244228 @default.
- W2000475291 creator A5074532120 @default.
- W2000475291 date "2014-06-19" @default.
- W2000475291 modified "2023-10-09" @default.
- W2000475291 title "Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, potentiate the anti-angiogenic effects of bevacizumab by suppressing angiopoietin2, BiP, and Hsp90α in human colorectal cancer" @default.
- W2000475291 cites W12110721 @default.
- W2000475291 cites W1963581413 @default.
- W2000475291 cites W1970614272 @default.
- W2000475291 cites W1982246723 @default.
- W2000475291 cites W1985670322 @default.
- W2000475291 cites W1996480660 @default.
- W2000475291 cites W2000975023 @default.
- W2000475291 cites W2023542270 @default.
- W2000475291 cites W2026184172 @default.
- W2000475291 cites W2028341910 @default.
- W2000475291 cites W2029201058 @default.
- W2000475291 cites W2035059839 @default.
- W2000475291 cites W2035269164 @default.
- W2000475291 cites W2037085464 @default.
- W2000475291 cites W2050445354 @default.
- W2000475291 cites W2054728198 @default.
- W2000475291 cites W2066888615 @default.
- W2000475291 cites W2071124826 @default.
- W2000475291 cites W2076981817 @default.
- W2000475291 cites W2078184649 @default.
- W2000475291 cites W2081596239 @default.
- W2000475291 cites W2092067196 @default.
- W2000475291 cites W2097840941 @default.
- W2000475291 cites W2101711321 @default.
- W2000475291 cites W2102025854 @default.
- W2000475291 cites W2112171202 @default.
- W2000475291 cites W2123834601 @default.
- W2000475291 cites W2125447919 @default.
- W2000475291 cites W2125756326 @default.
- W2000475291 cites W2139396663 @default.
- W2000475291 cites W2153346478 @default.
- W2000475291 cites W2157769714 @default.
- W2000475291 cites W2157985193 @default.
- W2000475291 cites W2164008484 @default.
- W2000475291 cites W2165741055 @default.
- W2000475291 cites W2170000965 @default.
- W2000475291 cites W2793323124 @default.
- W2000475291 cites W4236554944 @default.
- W2000475291 cites W4241333469 @default.
- W2000475291 cites W63483474 @default.
- W2000475291 doi "https://doi.org/10.1038/bjc.2014.283" @default.
- W2000475291 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4119970" @default.
- W2000475291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24945998" @default.
- W2000475291 hasPublicationYear "2014" @default.
- W2000475291 type Work @default.
- W2000475291 sameAs 2000475291 @default.
- W2000475291 citedByCount "39" @default.
- W2000475291 countsByYear W20004752912015 @default.
- W2000475291 countsByYear W20004752912016 @default.
- W2000475291 countsByYear W20004752912017 @default.
- W2000475291 countsByYear W20004752912018 @default.
- W2000475291 countsByYear W20004752912019 @default.
- W2000475291 countsByYear W20004752912020 @default.
- W2000475291 countsByYear W20004752912021 @default.
- W2000475291 countsByYear W20004752912022 @default.
- W2000475291 countsByYear W20004752912023 @default.
- W2000475291 crossrefType "journal-article" @default.
- W2000475291 hasAuthorship W2000475291A5021945651 @default.
- W2000475291 hasAuthorship W2000475291A5025758897 @default.
- W2000475291 hasAuthorship W2000475291A5040103448 @default.
- W2000475291 hasAuthorship W2000475291A5065244228 @default.
- W2000475291 hasAuthorship W2000475291A5074532120 @default.
- W2000475291 hasBestOaLocation W20004752911 @default.
- W2000475291 hasConcept C104950815 @default.
- W2000475291 hasConcept C121608353 @default.
- W2000475291 hasConcept C126322002 @default.
- W2000475291 hasConcept C134651460 @default.
- W2000475291 hasConcept C1491633281 @default.
- W2000475291 hasConcept C181199279 @default.
- W2000475291 hasConcept C185592680 @default.
- W2000475291 hasConcept C2776329913 @default.
- W2000475291 hasConcept C2776694085 @default.
- W2000475291 hasConcept C2776839432 @default.
- W2000475291 hasConcept C2777802072 @default.
- W2000475291 hasConcept C2778163477 @default.
- W2000475291 hasConcept C2780394083 @default.
- W2000475291 hasConcept C2780940807 @default.
- W2000475291 hasConcept C502942594 @default.
- W2000475291 hasConcept C526805850 @default.
- W2000475291 hasConcept C53227056 @default.
- W2000475291 hasConcept C55493867 @default.
- W2000475291 hasConcept C71924100 @default.
- W2000475291 hasConcept C98274493 @default.
- W2000475291 hasConceptScore W2000475291C104950815 @default.
- W2000475291 hasConceptScore W2000475291C121608353 @default.
- W2000475291 hasConceptScore W2000475291C126322002 @default.
- W2000475291 hasConceptScore W2000475291C134651460 @default.
- W2000475291 hasConceptScore W2000475291C1491633281 @default.