Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000475877> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2000475877 endingPage "135" @default.
- W2000475877 startingPage "128" @default.
- W2000475877 abstract "I believe streptokinase is still the trombolytic of choice for the majority of patients with acute myocardial infarction for the following reasons: 1. The superiority of alteplase over streptokinase rests on insecure grounds, statistically (when net clinical benefit is computed for the SK/subcutaneous heparin arm versus the accelerated t-PA arm, the P value is only 0.04). 2. The excess of cerebral haemorrhage with t-PA is statistically highly significant and consistent over all trials. 3. Patients at greater risk of cerebral hemorrhage are those with raised systolic arterial pressure above about 130 to 140 on admission and those aged over about 55 years. These comprise the majority of patients admitted to ordinary Coronary Care Units. If t-PA is given to patients at low risk of cerebral hemorrhage, the extra cost per life saved will be very high, since such patients are at relatively low risk in any case. 4. The open design of the GUSTO-2 trial (the only trial showing a small mortality benefit for accelerated t-PA versus SK) introduces the possibility of bias. For example, unfamiliarity with SK in North American centers may have given risk to premature stopping of treatment because of hypotension; this might have resulted in a more favorable experience for accelerated t-PA in North American centers compared with the rest of the world. (The mortality benefit for accelerated t-PA in the GUSTO trial was seen only in North American centers.)" @default.
- W2000475877 created "2016-06-24" @default.
- W2000475877 creator A5090093329 @default.
- W2000475877 date "1995-02-01" @default.
- W2000475877 modified "2023-09-27" @default.
- W2000475877 title "STREPTOKINASE IS STILL THE AGENT OF CHOICE FOR MOST PATIENTS WITH MYOCARDIAL INFARCTION" @default.
- W2000475877 doi "https://doi.org/10.1097/00045391-199502000-00009" @default.
- W2000475877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11847540" @default.
- W2000475877 hasPublicationYear "1995" @default.
- W2000475877 type Work @default.
- W2000475877 sameAs 2000475877 @default.
- W2000475877 citedByCount "7" @default.
- W2000475877 crossrefType "journal-article" @default.
- W2000475877 hasAuthorship W2000475877A5090093329 @default.
- W2000475877 hasConcept C126322002 @default.
- W2000475877 hasConcept C164705383 @default.
- W2000475877 hasConcept C194828623 @default.
- W2000475877 hasConcept C2776336681 @default.
- W2000475877 hasConcept C2777557582 @default.
- W2000475877 hasConcept C2779581417 @default.
- W2000475877 hasConcept C500558357 @default.
- W2000475877 hasConcept C71924100 @default.
- W2000475877 hasConceptScore W2000475877C126322002 @default.
- W2000475877 hasConceptScore W2000475877C164705383 @default.
- W2000475877 hasConceptScore W2000475877C194828623 @default.
- W2000475877 hasConceptScore W2000475877C2776336681 @default.
- W2000475877 hasConceptScore W2000475877C2777557582 @default.
- W2000475877 hasConceptScore W2000475877C2779581417 @default.
- W2000475877 hasConceptScore W2000475877C500558357 @default.
- W2000475877 hasConceptScore W2000475877C71924100 @default.
- W2000475877 hasIssue "2" @default.
- W2000475877 hasLocation W20004758771 @default.
- W2000475877 hasLocation W20004758772 @default.
- W2000475877 hasOpenAccess W2000475877 @default.
- W2000475877 hasPrimaryLocation W20004758771 @default.
- W2000475877 hasRelatedWork W152832745 @default.
- W2000475877 hasRelatedWork W1531506504 @default.
- W2000475877 hasRelatedWork W1561801847 @default.
- W2000475877 hasRelatedWork W1590096457 @default.
- W2000475877 hasRelatedWork W1596397105 @default.
- W2000475877 hasRelatedWork W1935688919 @default.
- W2000475877 hasRelatedWork W1945905736 @default.
- W2000475877 hasRelatedWork W1982490689 @default.
- W2000475877 hasRelatedWork W1996561823 @default.
- W2000475877 hasRelatedWork W2030677873 @default.
- W2000475877 hasRelatedWork W2068444886 @default.
- W2000475877 hasRelatedWork W2072988420 @default.
- W2000475877 hasRelatedWork W2082401117 @default.
- W2000475877 hasRelatedWork W2108219058 @default.
- W2000475877 hasRelatedWork W2113132440 @default.
- W2000475877 hasRelatedWork W2118372912 @default.
- W2000475877 hasRelatedWork W2413077448 @default.
- W2000475877 hasRelatedWork W2743014087 @default.
- W2000475877 hasRelatedWork W276549403 @default.
- W2000475877 hasRelatedWork W3097621226 @default.
- W2000475877 hasVolume "2" @default.
- W2000475877 isParatext "false" @default.
- W2000475877 isRetracted "false" @default.
- W2000475877 magId "2000475877" @default.
- W2000475877 workType "article" @default.