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• W2000477089 abstract "Recent epidemiological studies have shed new light on the contribution of underlying skeletal fragility to the occurrence of fractures in childhood. In addition, there have been important advances in our understanding of the factors that influence the development of skeletal traits in childhood, such as bone mass and bone size, which determine fracture risk in later life. These factors operating in childhood include potentially modifiable influences, such as physical activity and body composition, as well as prenatal/early life exposures, such as maternal vitamin D status in pregnancy. In addition, constitutional factors play an important role in skeletal development, particularly puberty and sex steroids. Several genetic polymorphisms have also been found to affect skeletal development; although exerting relatively small effects alone, emerging evidence suggests that genetic influences play an important role in childhood by altering the skeletal response to factors such as physical activity and puberty." @default.
• W2000477089 created "2016-06-24" @default.
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• W2000477089 date "2007-08-01" @default.
• W2000477089 modified "2023-10-16" @default.
• W2000477089 title "Epidemiological studies of osteoporosis in children" @default.
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• W2000477089 doi "https://doi.org/10.2217/17460816.2.4.391" @default.
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