FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000480111> ?p ?o ?g. }

• W2000480111 endingPage "1165" @default.
• W2000480111 startingPage "1158" @default.
• W2000480111 abstract "We have attempted to determine if the elevated plasma glucagon concentration and delayed MCR of glucagon (MCRg) observed during caloric restriction are related to the decreased serum T3 that also occurs during fasting. Twelve obese subjects received a 3-h iv glucagon infusion during a 4-day fed period (1000 kCal/day) and again on approximately the third fasting day. Five patients fasted without receiving exogenous T3 (control group), whereas seven subjects fasted but also received 5 micrograms T3 orally every 4 h (T3 group) to maintain approximately the same serum T3 levels in the fed and fasting periods. Glucagon production rates (GPR) were derived by multiplying the MCRg by the respective basal plasma glucogon concentrations. In the control group, the MCRg was 442 +/- 55 ml/m2 . min in the postabsorptive state and decreased to 312 +/- 49 ml/m2 . min (P < 0.025) during fasting, whereas in the T3-treated group, the postabsorptive MCRg was 304 +/- 22 ml/m2 . min and increased during fasting to 417 +/- 47 ml/m2 . min (P < 0.025). The GPRs in the control group were statistically unaltered between the fed (27.7 +/- 3.0 ng/m2 . min) and fasted (22.9 +/- 1.8 ng/m2 . min) intervals, but GPR increased from 37.9 +/- 6.1 ng/m2 . min during fasting to 49.2 +/- 9.1 ng/m2 . min when T3 was administered (5 micrograms every 4 h). The net plasma glucose increment in response to glucagon decreased from 18 mg/dl (fed) to 5 mg/dl (fast) in the control patients and from 10 mg/dl (fed) to 7 mg/dl (fast) in the T3-treated subjects. In the T3-treated patients, serum T3 averaged 124 ng/dl during both feeding and fasting, and rT3 was 55 +/- 6 ng/dl during feeding and 49 +/- 5 ng/dl during fasting. In summary, the results from this study indicate that during fasting 1) slight physiological alterations in serum T3 influence the MCRg, and 2) T3 increases the GPR and blocks the customary fasting-induced rise in rT3. Conceivably, decreased T3 is an early event in the fasting state which serves to decrease the MCRg, a process which subsequently regulates glucose homeostasis." @default.
• W2000480111 created "2016-06-24" @default.
• W2000480111 creator A5004080743 @default.
• W2000480111 creator A5010162812 @default.
• W2000480111 creator A5013056369 @default.
• W2000480111 creator A5036691736 @default.
• W2000480111 creator A5074325574 @default.
• W2000480111 creator A5077063444 @default.
• W2000480111 creator A5078847938 @default.
• W2000480111 date "1980-11-01" @default.
• W2000480111 modified "2023-10-18" @default.
• W2000480111 title "Glucagon Kinetics in Fasting: Physiological Elevations in Serum 3,5,3′-Triiodothyronine Increase the Metabolic Clearance Rate of Glucagon*" @default.
• W2000480111 cites W100113332 @default.
• W2000480111 cites W1525388209 @default.
• W2000480111 cites W1890340204 @default.
• W2000480111 cites W1967272642 @default.
• W2000480111 cites W1974554536 @default.
• W2000480111 cites W1982787158 @default.
• W2000480111 cites W1993649357 @default.
• W2000480111 cites W1999829148 @default.
• W2000480111 cites W2003019021 @default.
• W2000480111 cites W2017178736 @default.
• W2000480111 cites W2026015079 @default.
• W2000480111 cites W2039242258 @default.
• W2000480111 cites W2043217025 @default.
• W2000480111 cites W2044346387 @default.
• W2000480111 cites W2046334873 @default.
• W2000480111 cites W2060813749 @default.
• W2000480111 cites W2064799388 @default.
• W2000480111 cites W2070174457 @default.
• W2000480111 cites W2071602271 @default.
• W2000480111 cites W2072102228 @default.
• W2000480111 cites W2073409252 @default.
• W2000480111 cites W2081500798 @default.
• W2000480111 cites W2083740151 @default.
• W2000480111 cites W2084472942 @default.
• W2000480111 cites W2085861230 @default.
• W2000480111 cites W2088294557 @default.
• W2000480111 cites W2091828650 @default.
• W2000480111 cites W2094715960 @default.
• W2000480111 cites W2095263808 @default.
• W2000480111 cites W2102122484 @default.
• W2000480111 cites W2112538182 @default.
• W2000480111 cites W2116920167 @default.
• W2000480111 cites W2118032997 @default.
• W2000480111 cites W2136764645 @default.
• W2000480111 cites W2143873575 @default.
• W2000480111 cites W2151287684 @default.
• W2000480111 cites W2205422880 @default.
• W2000480111 cites W2320524529 @default.
• W2000480111 cites W2332286485 @default.
• W2000480111 cites W2336714744 @default.
• W2000480111 cites W52403050 @default.
• W2000480111 doi "https://doi.org/10.1210/jcem-51-5-1158" @default.
• W2000480111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7419689" @default.
• W2000480111 hasPublicationYear "1980" @default.
• W2000480111 type Work @default.
• W2000480111 sameAs 2000480111 @default.
• W2000480111 citedByCount "19" @default.
• W2000480111 countsByYear W20004801112013 @default.
• W2000480111 crossrefType "journal-article" @default.
• W2000480111 hasAuthorship W2000480111A5004080743 @default.
• W2000480111 hasAuthorship W2000480111A5010162812 @default.
• W2000480111 hasAuthorship W2000480111A5013056369 @default.
• W2000480111 hasAuthorship W2000480111A5036691736 @default.
• W2000480111 hasAuthorship W2000480111A5074325574 @default.
• W2000480111 hasAuthorship W2000480111A5077063444 @default.
• W2000480111 hasAuthorship W2000480111A5078847938 @default.
• W2000480111 hasConcept C126322002 @default.
• W2000480111 hasConcept C134018914 @default.
• W2000480111 hasConcept C185592680 @default.
• W2000480111 hasConcept C2778024521 @default.
• W2000480111 hasConcept C2778288131 @default.
• W2000480111 hasConcept C2778563252 @default.
• W2000480111 hasConcept C2779306644 @default.
• W2000480111 hasConcept C526584372 @default.
• W2000480111 hasConcept C71924100 @default.
• W2000480111 hasConceptScore W2000480111C126322002 @default.
• W2000480111 hasConceptScore W2000480111C134018914 @default.
• W2000480111 hasConceptScore W2000480111C185592680 @default.
• W2000480111 hasConceptScore W2000480111C2778024521 @default.
• W2000480111 hasConceptScore W2000480111C2778288131 @default.
• W2000480111 hasConceptScore W2000480111C2778563252 @default.
• W2000480111 hasConceptScore W2000480111C2779306644 @default.
• W2000480111 hasConceptScore W2000480111C526584372 @default.
• W2000480111 hasConceptScore W2000480111C71924100 @default.
• W2000480111 hasIssue "5" @default.
• W2000480111 hasLocation W20004801111 @default.
• W2000480111 hasLocation W20004801112 @default.
• W2000480111 hasOpenAccess W2000480111 @default.
• W2000480111 hasPrimaryLocation W20004801111 @default.
• W2000480111 hasRelatedWork W1964422326 @default.
• W2000480111 hasRelatedWork W1976823253 @default.
• W2000480111 hasRelatedWork W2002744316 @default.
• W2000480111 hasRelatedWork W2023948432 @default.
• W2000480111 hasRelatedWork W2075935248 @default.
• W2000480111 hasRelatedWork W2133799251 @default.
• W2000480111 hasRelatedWork W2145722810 @default.

• next