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- W2000480449 abstract "The effects of halothane, methoxyflurane, trichloroethylene, and chloroform on the oxidation of nicotinamide adenine dinudeotide (NAD)-linked substrates by isolated rat liver mitochondria were investigated. All four agents inhibited NADH oxidation at concentrations that did not affect respiration with succinate as the substrate. The mean inhibitory concentrations (±SD) for the abolition of stimulation of state IV respiration by ADP were: halothane 0.84 mM (±0.10 mM), methoxyflurane 1.05 mM (±0.25 mM), trichloroethylene 1.11 mM (±0.26 mM), and chloroform 2.62 mM (±0.45 mM). The clinical relevance of this inhibition of electron transfer is discussed." @default.
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- W2000480449 date "1973-10-01" @default.
- W2000480449 modified "2023-10-18" @default.
- W2000480449 title "THE INHIBITION OF MITOCHONDRIAL RESPIRATION BY INHALATIONAL ANAESTHETIC AGENTS" @default.
- W2000480449 doi "https://doi.org/10.1093/bja/45.10.1005" @default.
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