Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000481486> ?p ?o ?g. }
- W2000481486 endingPage "90" @default.
- W2000481486 startingPage "83" @default.
- W2000481486 abstract "Background The proportion of positive among examined lymph nodes (lymph node ratio [LNR]) has been recently proposed as an useful and easy-to-calculate prognostic factor for patients with cutaneous melanoma. However, its independence from the standard prognostic system TNM has not been formally proven in a large series of patients. Methods Patients with histologically proven cutaneous melanoma were identified from the Surveillance Epidemiology End Results database. Disease-specific survival was the clinical outcome of interest. The prognostic ability of conventional factors and LNR was assessed by multivariable survival analysis using the Cox regression model. Results Eligible patients (n = 8,177) were diagnosed with melanoma between 1998 and 2006. Among lymph node-positive cases (n = 3,872), most LNR values ranged from 1% to 10% (n = 2,187). In the whole series (≥5 lymph nodes examined) LNR significantly contributed to the Cox model independently of the TNM effect on survival (hazard ratio, 1.28; 95% confidence interval, 1.23–1.32; P < .0001). On subgroup analysis, the significant and independent prognostic value of LNR was confirmed both in patients with ≥10 lymph nodes examined (n = 4,381) and in those with TNM stage III disease (n = 3,658). In all cases, LNR increased the prognostic accuracy of the survival model. Conclusion In this large series of patients, the LNR independently predicted disease-specific survival, improving the prognostic accuracy of the TNM system. Accordingly, the LNR should be taken into account for the stratification of patients’ risk, both in clinical and research settings. The proportion of positive among examined lymph nodes (lymph node ratio [LNR]) has been recently proposed as an useful and easy-to-calculate prognostic factor for patients with cutaneous melanoma. However, its independence from the standard prognostic system TNM has not been formally proven in a large series of patients. Patients with histologically proven cutaneous melanoma were identified from the Surveillance Epidemiology End Results database. Disease-specific survival was the clinical outcome of interest. The prognostic ability of conventional factors and LNR was assessed by multivariable survival analysis using the Cox regression model. Eligible patients (n = 8,177) were diagnosed with melanoma between 1998 and 2006. Among lymph node-positive cases (n = 3,872), most LNR values ranged from 1% to 10% (n = 2,187). In the whole series (≥5 lymph nodes examined) LNR significantly contributed to the Cox model independently of the TNM effect on survival (hazard ratio, 1.28; 95% confidence interval, 1.23–1.32; P < .0001). On subgroup analysis, the significant and independent prognostic value of LNR was confirmed both in patients with ≥10 lymph nodes examined (n = 4,381) and in those with TNM stage III disease (n = 3,658). In all cases, LNR increased the prognostic accuracy of the survival model. In this large series of patients, the LNR independently predicted disease-specific survival, improving the prognostic accuracy of the TNM system. Accordingly, the LNR should be taken into account for the stratification of patients’ risk, both in clinical and research settings." @default.
- W2000481486 created "2016-06-24" @default.
- W2000481486 creator A5008759910 @default.
- W2000481486 creator A5009562018 @default.
- W2000481486 creator A5010324991 @default.
- W2000481486 creator A5089343179 @default.
- W2000481486 date "2011-07-01" @default.
- W2000481486 modified "2023-09-23" @default.
- W2000481486 title "Validation of the prognostic value of lymph node ratio in patients with cutaneous melanoma: A population-based study of 8,177 cases" @default.
- W2000481486 cites W1556015104 @default.
- W2000481486 cites W1967976312 @default.
- W2000481486 cites W1980662428 @default.
- W2000481486 cites W1997919830 @default.
- W2000481486 cites W2021329662 @default.
- W2000481486 cites W2023996790 @default.
- W2000481486 cites W2026680808 @default.
- W2000481486 cites W2029634303 @default.
- W2000481486 cites W2041890704 @default.
- W2000481486 cites W2049671177 @default.
- W2000481486 cites W2060900419 @default.
- W2000481486 cites W2063828623 @default.
- W2000481486 cites W2082327705 @default.
- W2000481486 cites W2088943471 @default.
- W2000481486 cites W2089589783 @default.
- W2000481486 cites W2096821264 @default.
- W2000481486 cites W2102127762 @default.
- W2000481486 cites W2122540164 @default.
- W2000481486 cites W2129925362 @default.
- W2000481486 cites W2132371956 @default.
- W2000481486 cites W2135032122 @default.
- W2000481486 cites W2136421130 @default.
- W2000481486 cites W2149407433 @default.
- W2000481486 cites W2152873514 @default.
- W2000481486 cites W2158299227 @default.
- W2000481486 cites W2169907009 @default.
- W2000481486 cites W2185055660 @default.
- W2000481486 cites W2318777050 @default.
- W2000481486 cites W4211125876 @default.
- W2000481486 cites W4244151305 @default.
- W2000481486 doi "https://doi.org/10.1016/j.surg.2011.02.021" @default.
- W2000481486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21683860" @default.
- W2000481486 hasPublicationYear "2011" @default.
- W2000481486 type Work @default.
- W2000481486 sameAs 2000481486 @default.
- W2000481486 citedByCount "22" @default.
- W2000481486 countsByYear W20004814862012 @default.
- W2000481486 countsByYear W20004814862013 @default.
- W2000481486 countsByYear W20004814862014 @default.
- W2000481486 countsByYear W20004814862015 @default.
- W2000481486 countsByYear W20004814862016 @default.
- W2000481486 countsByYear W20004814862017 @default.
- W2000481486 countsByYear W20004814862018 @default.
- W2000481486 countsByYear W20004814862020 @default.
- W2000481486 countsByYear W20004814862021 @default.
- W2000481486 crossrefType "journal-article" @default.
- W2000481486 hasAuthorship W2000481486A5008759910 @default.
- W2000481486 hasAuthorship W2000481486A5009562018 @default.
- W2000481486 hasAuthorship W2000481486A5010324991 @default.
- W2000481486 hasAuthorship W2000481486A5089343179 @default.
- W2000481486 hasConcept C10515644 @default.
- W2000481486 hasConcept C107130276 @default.
- W2000481486 hasConcept C126322002 @default.
- W2000481486 hasConcept C142724271 @default.
- W2000481486 hasConcept C143998085 @default.
- W2000481486 hasConcept C146357865 @default.
- W2000481486 hasConcept C151730666 @default.
- W2000481486 hasConcept C207103383 @default.
- W2000481486 hasConcept C2777658100 @default.
- W2000481486 hasConcept C2779720271 @default.
- W2000481486 hasConcept C2780849966 @default.
- W2000481486 hasConcept C2908647359 @default.
- W2000481486 hasConcept C44249647 @default.
- W2000481486 hasConcept C502942594 @default.
- W2000481486 hasConcept C50382708 @default.
- W2000481486 hasConcept C71924100 @default.
- W2000481486 hasConcept C86803240 @default.
- W2000481486 hasConcept C99454951 @default.
- W2000481486 hasConceptScore W2000481486C10515644 @default.
- W2000481486 hasConceptScore W2000481486C107130276 @default.
- W2000481486 hasConceptScore W2000481486C126322002 @default.
- W2000481486 hasConceptScore W2000481486C142724271 @default.
- W2000481486 hasConceptScore W2000481486C143998085 @default.
- W2000481486 hasConceptScore W2000481486C146357865 @default.
- W2000481486 hasConceptScore W2000481486C151730666 @default.
- W2000481486 hasConceptScore W2000481486C207103383 @default.
- W2000481486 hasConceptScore W2000481486C2777658100 @default.
- W2000481486 hasConceptScore W2000481486C2779720271 @default.
- W2000481486 hasConceptScore W2000481486C2780849966 @default.
- W2000481486 hasConceptScore W2000481486C2908647359 @default.
- W2000481486 hasConceptScore W2000481486C44249647 @default.
- W2000481486 hasConceptScore W2000481486C502942594 @default.
- W2000481486 hasConceptScore W2000481486C50382708 @default.
- W2000481486 hasConceptScore W2000481486C71924100 @default.
- W2000481486 hasConceptScore W2000481486C86803240 @default.
- W2000481486 hasConceptScore W2000481486C99454951 @default.
- W2000481486 hasIssue "1" @default.
- W2000481486 hasLocation W20004814861 @default.
- W2000481486 hasLocation W20004814862 @default.