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• W2000481871 abstract "Significance How cells position their proteins is still an open question. Here, we propose a physical description of centrosomes, which are membraneless organelles involved in cell division. In our model, centrosome material occurs in a soluble form and a form that tends to form droplets by phase separation. We find that an autocatalytic chemical transition between these forms quantitatively accounts for our experimental data. Importantly, a catalytic activity of the centrioles, which are located inside centrosomes, can control centrosome nucleation and suppress Ostwald ripening to allow for two equal-sized centrosomes to coexist in the cell. Consequently, our example shows how the combination of chemical reactions and phase separation can be used to control the formation of liquid-like compartments in cells." @default.
• W2000481871 created "2016-06-24" @default.
• W2000481871 creator A5061394488 @default.
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• W2000481871 date "2014-06-16" @default.
• W2000481871 modified "2023-10-11" @default.
• W2000481871 title "Centrosomes are autocatalytic droplets of pericentriolar material organized by centrioles" @default.
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• W2000481871 doi "https://doi.org/10.1073/pnas.1404855111" @default.
• W2000481871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4084434" @default.
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