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- W2000482592 abstract "Congenital or hereditary myasthenia describes a heterogeneous group of disorders in which the immune system is not implicated. Treatment has previously depended on anticholinesterase medication. The effectiveness of 3,4-diaminopyridine (3,4-DAP), a preparation that enhances acetylcholine release from motor nerve terminals, has been evaluated using a series of standardised strength measures. Sixteen patients (aged seven to 47 years) were studied in an open prospective trial, and four of them in a double blind crossover trial; existing anticholinesterase medication was continued. For the group as a whole, there was a highly significant increase in muscle strength (p less than 0.001; n = 16). In individual paired comparisons, 13 out of 16 showed significant improvement in the open trial and four out of four in the blind crossover trial. In conclusion, 3,4-DAP, either alone or combined with anticholinesterase medication, may be a useful additional treatment in congenital myasthenia." @default.
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- W2000482592 date "1991-12-01" @default.
- W2000482592 modified "2023-09-26" @default.
- W2000482592 title "3.4 Diaminopyridine in the treatment of congenital (hereditary) myasthenia" @default.
- W2000482592 doi "https://doi.org/10.1016/0896-8411(91)90120-2" @default.
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