FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W200048328> ?p ?o ?g. }

• W200048328 endingPage "1299" @default.
• W200048328 startingPage "1285" @default.
• W200048328 abstract "The baboon response to intravenous infusion of Shiga toxin 1 (Stx-1) varied from acute renal failure, proteinuria, hyperkalemia, and melena with minimal perturbation of host inflammatory and hemostatic systems (high-dose group, 2.0 microg/kg; n = 5) to renal failure with hematuria, proteinuria, thrombocytopenia, schistocytosis, anemia, and melena (low-dose group, 0.05 to 0.2 microg/kg; n = 8). Both groups exhibited renal shutdown and died in 57 hours or less. Both groups produced urine that was positive for tumor necrosis factor and interleukin-6 although neither of these cytokines was detectable (</=5 ng/ml) in the general circulation. Light and electron microscopy showed organelle disintegration and necrosis of the renal proximal tubular epithelium and of the intestinal mucosal epithelium at the tips of the microvilli, both of which were previously shown to bear Gb3 receptors. The renal distal tubular epithelium was spared. The renal proximal tubular epithelial changes were accompanied by swelling of visceral epithelial cells (podocytes) and by swelling and detachment of endothelial cells of the glomerular capillaries. In addition, all of the animals receiving low-dose Stx-1 showed microvascular fibrin deposition and thrombosis in renal glomerular and peritubular capillaries in association with a fall in hematocrit and platelet count and a rise in schistocyte count. The gastrointestinal villous tip lesions were accompanied by varying degrees of mucosal and submucosal congestion, hemorrhage, or necrosis. Electron microscopic images of cerebral cortex and cerebellum showed diffuse unraveling of myelin sheaths with occasional disintegration of neuronal cell bodies. In contrast to the gastrointestinal mucosal and renal proximal tubular epithelium, the Gb3 receptor glycolipid of the renal glomerular and neuronal tissues as determined using toxin overlay thin-layer chromatography plates was below the limit of detection (<13 pM/g wet tissue). We conclude that, depending on the status of the host and amount of toxin infused, Stx-1 can produce a variety of responses ranging from damage to cells carrying the Gb3 receptor (renal proximal tubular epithelial cells and gastrointestinal mucosa) to damage to renal glomerular tissues with microvascular thrombosis as a result of the host's inflammatory response localized to the kidney. We conclude that this thrombotic coagulopathy arises from local changes in the kidney because the appearance of host inflammatory mediators was limited to the urine. This suggests that the initial host response is localized in the kidney, and that the systemic thrombocytopenia, anemia, and schistocytosis may arise secondarily." @default.
• W200048328 created "2016-06-24" @default.
• W200048328 creator A5022677803 @default.
• W200048328 creator A5025325201 @default.
• W200048328 creator A5033454609 @default.
• W200048328 creator A5056158088 @default.
• W200048328 creator A5068218416 @default.
• W200048328 creator A5069270697 @default.
• W200048328 creator A5076458296 @default.
• W200048328 creator A5088187025 @default.
• W200048328 date "1999-04-01" @default.
• W200048328 modified "2023-10-17" @default.
• W200048328 title "Characterization of the Baboon Responses to Shiga-Like Toxin" @default.
• W200048328 cites W1509718829 @default.
• W200048328 cites W1511443044 @default.
• W200048328 cites W1534382357 @default.
• W200048328 cites W1560182594 @default.
• W200048328 cites W1561749999 @default.
• W200048328 cites W1569412890 @default.
• W200048328 cites W1591377255 @default.
• W200048328 cites W167520159 @default.
• W200048328 cites W171066690 @default.
• W200048328 cites W1805879606 @default.
• W200048328 cites W1809071149 @default.
• W200048328 cites W1891701312 @default.
• W200048328 cites W1907128661 @default.
• W200048328 cites W1915232937 @default.
• W200048328 cites W1915521551 @default.
• W200048328 cites W1917885463 @default.
• W200048328 cites W1942715185 @default.
• W200048328 cites W1972592378 @default.
• W200048328 cites W1975432453 @default.
• W200048328 cites W1980082706 @default.
• W200048328 cites W1980315401 @default.
• W200048328 cites W1995610766 @default.
• W200048328 cites W2011718752 @default.
• W200048328 cites W2032713940 @default.
• W200048328 cites W2033748051 @default.
• W200048328 cites W2049546988 @default.
• W200048328 cites W2050374685 @default.
• W200048328 cites W2051673091 @default.
• W200048328 cites W2052398986 @default.
• W200048328 cites W2057077203 @default.
• W200048328 cites W2062440275 @default.
• W200048328 cites W2064458616 @default.
• W200048328 cites W2075241978 @default.
• W200048328 cites W2086260154 @default.
• W200048328 cites W2099062847 @default.
• W200048328 cites W2109138592 @default.
• W200048328 cites W2109205313 @default.
• W200048328 cites W2117740276 @default.
• W200048328 cites W2123994723 @default.
• W200048328 cites W2124470669 @default.
• W200048328 cites W2129052562 @default.
• W200048328 cites W2142596760 @default.
• W200048328 cites W2145926928 @default.
• W200048328 cites W2153636555 @default.
• W200048328 cites W2156327171 @default.
• W200048328 cites W2157584173 @default.
• W200048328 cites W2166761865 @default.
• W200048328 cites W2167966545 @default.
• W200048328 cites W2331363560 @default.
• W200048328 cites W2331378402 @default.
• W200048328 cites W2406816100 @default.
• W200048328 cites W2417221154 @default.
• W200048328 cites W2418367768 @default.
• W200048328 cites W2418638519 @default.
• W200048328 cites W2419158960 @default.
• W200048328 cites W2441067267 @default.
• W200048328 cites W2460155410 @default.
• W200048328 doi "https://doi.org/10.1016/s0002-9440(10)65380-1" @default.
• W200048328 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1866558" @default.
• W200048328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10233866" @default.
• W200048328 hasPublicationYear "1999" @default.
• W200048328 type Work @default.
• W200048328 sameAs 200048328 @default.
• W200048328 citedByCount "127" @default.
• W200048328 countsByYear W2000483282012 @default.
• W200048328 countsByYear W2000483282013 @default.
• W200048328 countsByYear W2000483282014 @default.
• W200048328 countsByYear W2000483282015 @default.
• W200048328 countsByYear W2000483282016 @default.
• W200048328 countsByYear W2000483282017 @default.
• W200048328 countsByYear W2000483282018 @default.
• W200048328 countsByYear W2000483282019 @default.
• W200048328 countsByYear W2000483282021 @default.
• W200048328 countsByYear W2000483282022 @default.
• W200048328 countsByYear W2000483282023 @default.
• W200048328 crossrefType "journal-article" @default.
• W200048328 hasAuthorship W200048328A5022677803 @default.
• W200048328 hasAuthorship W200048328A5025325201 @default.
• W200048328 hasAuthorship W200048328A5033454609 @default.
• W200048328 hasAuthorship W200048328A5056158088 @default.
• W200048328 hasAuthorship W200048328A5068218416 @default.
• W200048328 hasAuthorship W200048328A5069270697 @default.
• W200048328 hasAuthorship W200048328A5076458296 @default.
• W200048328 hasAuthorship W200048328A5088187025 @default.
• W200048328 hasBestOaLocation W2000483282 @default.

• next