FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000483350> ?p ?o ?g. }

• W2000483350 endingPage "1960" @default.
• W2000483350 startingPage "1952" @default.
• W2000483350 abstract "The laminin alpha3 chain LG4 module (alpha3LG4 module) has cell adhesion, heparin binding, migration, and neurite outgrowth activities. The LG4 module consists of a 14-stranded beta-sheet (A-N) sandwich structure. Previously, we identified the A3G756 sequence (KNSFMALYLSKGRLVFALG in the human laminin alpha3 chain 1411-1429) as a biologically active site in the alpha3LG4 module. The A3G756 sequence is located on the E and F strands based on a crystal structure-based sequence alignment. The Lys1421 and Arg1423 residues, critical amino acids for the biological activity of A3G756, are located on the E-F connecting loop region as a KGR sequence. In this study, we focused on the KGR sequence and investigated the structural requirements of the E-F connecting loop region in the alpha3LG4 module. We synthesized three linear peptides containing the KGR sequence at the middle and the N and C termini and also prepared three cyclic analogues corresponding to the linear peptides. cyclo-hEF3A (CLYLSKGRLVFAC), which is a cyclic peptide containing the KGR sequence at the middle, showed the strongest inhibitory effect on both the heparin binding and the cell attachment to the recombinant alpha3LG4 module protein. The cyclo-hEF3A peptide was more active for syndecan-4 binding and neurite outgrowth than the linear form. Furthermore, we found that the structure of cyclo-hEF3A is similar to that of the connecting E-F loop region in human laminin alpha3LG4 module by structural analysis using molecular dynamics simulations. These results suggest that the loop structure of the E-F connecting region of the alpha3LG4 module is important for its biological activities. The cyclo-hEF3A peptide may be useful for the development of therapeutic reagents especially for wound healing and nerve regeneration." @default.
• W2000483350 created "2016-06-24" @default.
• W2000483350 creator A5000257639 @default.
• W2000483350 creator A5010957149 @default.
• W2000483350 creator A5022685067 @default.
• W2000483350 creator A5033128839 @default.
• W2000483350 creator A5033456857 @default.
• W2000483350 creator A5045822295 @default.
• W2000483350 creator A5050071441 @default.
• W2000483350 creator A5056979882 @default.
• W2000483350 creator A5062788340 @default.
• W2000483350 creator A5075439930 @default.
• W2000483350 creator A5090371447 @default.
• W2000483350 date "2007-01-30" @default.
• W2000483350 modified "2023-10-18" @default.
• W2000483350 title "Cyclic Peptide Analysis of the Biologically Active Loop Region in the Laminin α3 Chain LG4 Module Demonstrates the Importance of Peptide Conformation on Biological Activity" @default.
• W2000483350 cites W1494668971 @default.
• W2000483350 cites W1523307634 @default.
• W2000483350 cites W1607041879 @default.
• W2000483350 cites W1618088704 @default.
• W2000483350 cites W1966682240 @default.
• W2000483350 cites W1995515274 @default.
• W2000483350 cites W1999815859 @default.
• W2000483350 cites W2006110187 @default.
• W2000483350 cites W2007968437 @default.
• W2000483350 cites W2010912149 @default.
• W2000483350 cites W2017963157 @default.
• W2000483350 cites W2019574809 @default.
• W2000483350 cites W2020524505 @default.
• W2000483350 cites W2053037734 @default.
• W2000483350 cites W2061803112 @default.
• W2000483350 cites W2067999123 @default.
• W2000483350 cites W2074012988 @default.
• W2000483350 cites W2081628019 @default.
• W2000483350 cites W2106140689 @default.
• W2000483350 cites W2122199548 @default.
• W2000483350 cites W2132895270 @default.
• W2000483350 cites W2139220860 @default.
• W2000483350 cites W2143987989 @default.
• W2000483350 cites W2148399778 @default.
• W2000483350 cites W2155687693 @default.
• W2000483350 cites W2443919280 @default.
• W2000483350 doi "https://doi.org/10.1021/bi062098l" @default.
• W2000483350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17261031" @default.
• W2000483350 hasPublicationYear "2007" @default.
• W2000483350 type Work @default.
• W2000483350 sameAs 2000483350 @default.
• W2000483350 citedByCount "6" @default.
• W2000483350 countsByYear W20004833502014 @default.
• W2000483350 countsByYear W20004833502020 @default.
• W2000483350 crossrefType "journal-article" @default.
• W2000483350 hasAuthorship W2000483350A5000257639 @default.
• W2000483350 hasAuthorship W2000483350A5010957149 @default.
• W2000483350 hasAuthorship W2000483350A5022685067 @default.
• W2000483350 hasAuthorship W2000483350A5033128839 @default.
• W2000483350 hasAuthorship W2000483350A5033456857 @default.
• W2000483350 hasAuthorship W2000483350A5045822295 @default.
• W2000483350 hasAuthorship W2000483350A5050071441 @default.
• W2000483350 hasAuthorship W2000483350A5056979882 @default.
• W2000483350 hasAuthorship W2000483350A5062788340 @default.
• W2000483350 hasAuthorship W2000483350A5075439930 @default.
• W2000483350 hasAuthorship W2000483350A5090371447 @default.
• W2000483350 hasConcept C104317684 @default.
• W2000483350 hasConcept C12554922 @default.
• W2000483350 hasConcept C1491633281 @default.
• W2000483350 hasConcept C153911025 @default.
• W2000483350 hasConcept C167625842 @default.
• W2000483350 hasConcept C185592680 @default.
• W2000483350 hasConcept C2778112365 @default.
• W2000483350 hasConcept C2779281246 @default.
• W2000483350 hasConcept C2779814568 @default.
• W2000483350 hasConcept C55493867 @default.
• W2000483350 hasConcept C60984968 @default.
• W2000483350 hasConcept C71240020 @default.
• W2000483350 hasConcept C86803240 @default.
• W2000483350 hasConceptScore W2000483350C104317684 @default.
• W2000483350 hasConceptScore W2000483350C12554922 @default.
• W2000483350 hasConceptScore W2000483350C1491633281 @default.
• W2000483350 hasConceptScore W2000483350C153911025 @default.
• W2000483350 hasConceptScore W2000483350C167625842 @default.
• W2000483350 hasConceptScore W2000483350C185592680 @default.
• W2000483350 hasConceptScore W2000483350C2778112365 @default.
• W2000483350 hasConceptScore W2000483350C2779281246 @default.
• W2000483350 hasConceptScore W2000483350C2779814568 @default.
• W2000483350 hasConceptScore W2000483350C55493867 @default.
• W2000483350 hasConceptScore W2000483350C60984968 @default.
• W2000483350 hasConceptScore W2000483350C71240020 @default.
• W2000483350 hasConceptScore W2000483350C86803240 @default.
• W2000483350 hasIssue "7" @default.
• W2000483350 hasLocation W20004833501 @default.
• W2000483350 hasLocation W20004833502 @default.
• W2000483350 hasOpenAccess W2000483350 @default.
• W2000483350 hasPrimaryLocation W20004833501 @default.
• W2000483350 hasRelatedWork W139533369 @default.
• W2000483350 hasRelatedWork W2027172366 @default.
• W2000483350 hasRelatedWork W2043558635 @default.
• W2000483350 hasRelatedWork W2154352199 @default.
• W2000483350 hasRelatedWork W2573214455 @default.

• next