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- W2000483565 abstract "Huntington disease (HD) is a progressive neurodegenerative disorder characterized by emotional, cognitive, and motor dysfunctions. Aggregation of huntingtin is a hallmark of HD and, therefore, a crucial parameter for the evaluation of HD animal models. We investigated here the regional, cellular, and subcellular distribution of N-terminal huntingtin aggregates and associated neuropathological changes in the forebrain of a rat transgenic for HD (tgHD). The tgHD rat brain showed enormously enlarged lateral ventricles and a similar atrophy of cortical and subcortical areas as known in HD patients. Huntingtin aggregates of varying size and forms were regionally identified in neuronal nuclei, cytoplasm, dendrites, dendritic spines, axons, and synaptic terminals, closely resembling the results described earlier for human HD brains and in established HD mouse models. Huntingtin aggregates in mitochondria support mitochondrial dysfunction as contributing to the disease pathogenesis. Dark cell degeneration was reminiscent of results in HD individuals and HD mouse models. Interestingly, huntingtin aggregates were especially well accumulated in two interacting limbic forebrain systems, the ventral striatopallidum and the extended amygdala, which may contribute to the early onset of emotional changes observed in the tgHD rat. In conclusion, the tgHD rat model reflects to a remarkable extent the cellular and subcellular neuropathological key features as observed in human HD and HD mouse brains and hints of changes in limbic forebrain systems, which may elucidate the emotional dysfunction in the tgHD rat and affective disturbances in HD patients. J. Comp. Neurol. 501:716–730, 2007. © 2007 Wiley-Liss, Inc." @default.
- W2000483565 created "2016-06-24" @default.
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- W2000483565 date "2007-01-01" @default.
- W2000483565 modified "2023-10-02" @default.
- W2000483565 title "Cellular and subcellular localization of Huntington aggregates in the brain of a rat transgenic for Huntington disease" @default.
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- W2000483565 cites W1962249623 @default.
- W2000483565 cites W1964003429 @default.
- W2000483565 cites W1965492289 @default.
- W2000483565 cites W1972771185 @default.
- W2000483565 cites W1985474993 @default.
- W2000483565 cites W1990406694 @default.
- W2000483565 cites W1992488134 @default.
- W2000483565 cites W1995119071 @default.
- W2000483565 cites W1995162780 @default.
- W2000483565 cites W1998974178 @default.
- W2000483565 cites W2005111389 @default.
- W2000483565 cites W2007640162 @default.
- W2000483565 cites W2014400669 @default.
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- W2000483565 cites W2018367299 @default.
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- W2000483565 cites W2021399948 @default.
- W2000483565 cites W2024618140 @default.
- W2000483565 cites W2026995370 @default.
- W2000483565 cites W2033742776 @default.
- W2000483565 cites W2041294105 @default.
- W2000483565 cites W2042716629 @default.
- W2000483565 cites W2044301772 @default.
- W2000483565 cites W2048320127 @default.
- W2000483565 cites W2052999354 @default.
- W2000483565 cites W2053985220 @default.
- W2000483565 cites W2054855746 @default.
- W2000483565 cites W2055310761 @default.
- W2000483565 cites W2060148506 @default.
- W2000483565 cites W2062682951 @default.
- W2000483565 cites W2064114794 @default.
- W2000483565 cites W2064560593 @default.
- W2000483565 cites W2067709327 @default.
- W2000483565 cites W2070381032 @default.
- W2000483565 cites W2072462108 @default.
- W2000483565 cites W2081023593 @default.
- W2000483565 cites W2081868255 @default.
- W2000483565 cites W2084849755 @default.
- W2000483565 cites W2088371437 @default.
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- W2000483565 cites W2170256902 @default.
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- W2000483565 cites W2171370174 @default.
- W2000483565 cites W2171705617 @default.
- W2000483565 cites W2484089597 @default.
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- W2000483565 doi "https://doi.org/10.1002/cne.21272" @default.
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