FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000483679> ?p ?o ?g. }

• W2000483679 endingPage "427" @default.
• W2000483679 startingPage "421" @default.
• W2000483679 abstract "Human tissues and cells express three AMP deaminase (AMPD) isoforms containing divergent N-terminal domains, and each member of the multigene family encoding these enzymes produces alternative transcripts that confer additional N-terminal divergence through extensions and cassette-type substitutions. Available data suggest that divergent N-terminal domains can influence AMPD isoform behavior, but the functional significance for additional divergence within each enzyme is unknown. Three isoform L (AMPD2) variants, 1A/2, 1B/2, and 1B/3, contain N-terminal extensions of 47, 128, and 53 amino acids, respectively. This study has determined the kinetic and regulatory behaviors of these three isoform L enzymes in the presence of positive (ATP) and negative (phosphate) allosteric effectors. All display nearly identical kinetic parameters and regulatory responses in the presence of phosphate alone, or in combination with ATP. Regulation by ATP is biphasic and the three isoform L enzymes also exhibit similar activation profiles and maximum initial velocities at 2–3 mM in the presence of 1 mM phosphate, whereas higher concentrations of phosphate suppress this activation. However, maximum initial velocities are achieved at lower ATP concentrations (0.8–1.5 mM) in the absence of phosphate and under these conditions 1B/2 is less active, 1B/3 is more active, and 1A/2 is similarly active when compared to 1 mM phosphate over the range of ATP concentrations found in non-muscle cells (0.8–3.7 mM). These combined results suggest that isoform L enzymes are designed to function under different metabolic conditions encountered in the non-striated muscle environments where they are expressed." @default.
• W2000483679 created "2016-06-24" @default.
• W2000483679 creator A5012442571 @default.
• W2000483679 creator A5085453835 @default.
• W2000483679 date "2003-05-01" @default.
• W2000483679 modified "2023-10-02" @default.
• W2000483679 title "N-terminal extensions of the human AMPD2 polypeptide influence ATP regulation of isoform L" @default.
• W2000483679 cites W1483243895 @default.
• W2000483679 cites W1485278922 @default.
• W2000483679 cites W1522175398 @default.
• W2000483679 cites W1561551012 @default.
• W2000483679 cites W1562998562 @default.
• W2000483679 cites W1563971849 @default.
• W2000483679 cites W1567446278 @default.
• W2000483679 cites W1579697362 @default.
• W2000483679 cites W1586293403 @default.
• W2000483679 cites W1678548139 @default.
• W2000483679 cites W1792542720 @default.
• W2000483679 cites W1956273663 @default.
• W2000483679 cites W1964186168 @default.
• W2000483679 cites W1965326676 @default.
• W2000483679 cites W1966217651 @default.
• W2000483679 cites W1968777484 @default.
• W2000483679 cites W1969914617 @default.
• W2000483679 cites W1984705139 @default.
• W2000483679 cites W1987416444 @default.
• W2000483679 cites W2005220257 @default.
• W2000483679 cites W2008163570 @default.
• W2000483679 cites W2010168295 @default.
• W2000483679 cites W2031511126 @default.
• W2000483679 cites W2032498082 @default.
• W2000483679 cites W2036652658 @default.
• W2000483679 cites W2056201729 @default.
• W2000483679 cites W2074303863 @default.
• W2000483679 cites W2076451352 @default.
• W2000483679 cites W2078827546 @default.
• W2000483679 cites W2086628507 @default.
• W2000483679 cites W2089475204 @default.
• W2000483679 cites W2094017851 @default.
• W2000483679 cites W2095539628 @default.
• W2000483679 cites W2100837269 @default.
• W2000483679 cites W2147814596 @default.
• W2000483679 cites W2158013993 @default.
• W2000483679 cites W2176711926 @default.
• W2000483679 cites W2199803239 @default.
• W2000483679 cites W2396499171 @default.
• W2000483679 cites W2414754506 @default.
• W2000483679 cites W2416874933 @default.
• W2000483679 cites W4236164632 @default.
• W2000483679 cites W4293247451 @default.
• W2000483679 cites W2064425018 @default.
• W2000483679 doi "https://doi.org/10.1016/s0006-291x(03)00787-3" @default.
• W2000483679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12745092" @default.
• W2000483679 hasPublicationYear "2003" @default.
• W2000483679 type Work @default.
• W2000483679 sameAs 2000483679 @default.
• W2000483679 citedByCount "11" @default.
• W2000483679 countsByYear W20004836792012 @default.
• W2000483679 countsByYear W20004836792017 @default.
• W2000483679 countsByYear W20004836792018 @default.
• W2000483679 crossrefType "journal-article" @default.
• W2000483679 hasAuthorship W2000483679A5012442571 @default.
• W2000483679 hasAuthorship W2000483679A5085453835 @default.
• W2000483679 hasConcept C104317684 @default.
• W2000483679 hasConcept C119795356 @default.
• W2000483679 hasConcept C165912504 @default.
• W2000483679 hasConcept C166342909 @default.
• W2000483679 hasConcept C181199279 @default.
• W2000483679 hasConcept C185592680 @default.
• W2000483679 hasConcept C2777132085 @default.
• W2000483679 hasConcept C34628245 @default.
• W2000483679 hasConcept C41183919 @default.
• W2000483679 hasConcept C515207424 @default.
• W2000483679 hasConcept C53345823 @default.
• W2000483679 hasConcept C55493867 @default.
• W2000483679 hasConcept C56856141 @default.
• W2000483679 hasConcept C74539022 @default.
• W2000483679 hasConcept C86803240 @default.
• W2000483679 hasConceptScore W2000483679C104317684 @default.
• W2000483679 hasConceptScore W2000483679C119795356 @default.
• W2000483679 hasConceptScore W2000483679C165912504 @default.
• W2000483679 hasConceptScore W2000483679C166342909 @default.
• W2000483679 hasConceptScore W2000483679C181199279 @default.
• W2000483679 hasConceptScore W2000483679C185592680 @default.
• W2000483679 hasConceptScore W2000483679C2777132085 @default.
• W2000483679 hasConceptScore W2000483679C34628245 @default.
• W2000483679 hasConceptScore W2000483679C41183919 @default.
• W2000483679 hasConceptScore W2000483679C515207424 @default.
• W2000483679 hasConceptScore W2000483679C53345823 @default.
• W2000483679 hasConceptScore W2000483679C55493867 @default.
• W2000483679 hasConceptScore W2000483679C56856141 @default.
• W2000483679 hasConceptScore W2000483679C74539022 @default.
• W2000483679 hasConceptScore W2000483679C86803240 @default.
• W2000483679 hasIssue "2" @default.
• W2000483679 hasLocation W20004836791 @default.
• W2000483679 hasLocation W20004836792 @default.
• W2000483679 hasOpenAccess W2000483679 @default.
• W2000483679 hasPrimaryLocation W20004836791 @default.

• next