Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000483770> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2000483770 endingPage "25" @default.
- W2000483770 startingPage "18" @default.
- W2000483770 abstract "Based on both IC50 and Ki values, brodimoprim (BDP) was often found to be two- to threefold more effective than trimethoprim (TMP) against a great variety of different bacterial dihydrofolate reductases (DHFR). In all cases BDP was found to be a reversible, tight-binding inhibitor. The higher affinity for enzymes relatively insensitive to TMP, like those of Nocardia, which is paralleled by higher in vitro activity, may be therapeutically useful. BDP also often inhibited plasmid-coded, TMP-resistant DHFRs, as well as altered chromosomal TMP-resistant DHFRs at lower concentrations than TMP did, this property, however, being therapeutically irrelevant. A higher affinity was also observed for eucaryotic DHFRs, the specificity, however, remaining similar to that of TMP." @default.
- W2000483770 created "2016-06-24" @default.
- W2000483770 creator A5004894040 @default.
- W2000483770 creator A5007952962 @default.
- W2000483770 date "1984-01-01" @default.
- W2000483770 modified "2023-09-25" @default.
- W2000483770 title "Properties of Brodimoprim as an Inhibitor of Dihydrofolate Reductases" @default.
- W2000483770 doi "https://doi.org/10.1159/000238239" @default.
- W2000483770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6363003" @default.
- W2000483770 hasPublicationYear "1984" @default.
- W2000483770 type Work @default.
- W2000483770 sameAs 2000483770 @default.
- W2000483770 citedByCount "21" @default.
- W2000483770 countsByYear W20004837702012 @default.
- W2000483770 crossrefType "journal-article" @default.
- W2000483770 hasAuthorship W2000483770A5004894040 @default.
- W2000483770 hasAuthorship W2000483770A5007952962 @default.
- W2000483770 hasConcept C181199279 @default.
- W2000483770 hasConcept C185592680 @default.
- W2000483770 hasConcept C202751555 @default.
- W2000483770 hasConcept C2776060363 @default.
- W2000483770 hasConcept C2779448432 @default.
- W2000483770 hasConcept C2779920670 @default.
- W2000483770 hasConcept C2780728791 @default.
- W2000483770 hasConcept C2781320022 @default.
- W2000483770 hasConcept C501593827 @default.
- W2000483770 hasConcept C523546767 @default.
- W2000483770 hasConcept C54355233 @default.
- W2000483770 hasConcept C55493867 @default.
- W2000483770 hasConcept C71240020 @default.
- W2000483770 hasConcept C86803240 @default.
- W2000483770 hasConcept C89423630 @default.
- W2000483770 hasConceptScore W2000483770C181199279 @default.
- W2000483770 hasConceptScore W2000483770C185592680 @default.
- W2000483770 hasConceptScore W2000483770C202751555 @default.
- W2000483770 hasConceptScore W2000483770C2776060363 @default.
- W2000483770 hasConceptScore W2000483770C2779448432 @default.
- W2000483770 hasConceptScore W2000483770C2779920670 @default.
- W2000483770 hasConceptScore W2000483770C2780728791 @default.
- W2000483770 hasConceptScore W2000483770C2781320022 @default.
- W2000483770 hasConceptScore W2000483770C501593827 @default.
- W2000483770 hasConceptScore W2000483770C523546767 @default.
- W2000483770 hasConceptScore W2000483770C54355233 @default.
- W2000483770 hasConceptScore W2000483770C55493867 @default.
- W2000483770 hasConceptScore W2000483770C71240020 @default.
- W2000483770 hasConceptScore W2000483770C86803240 @default.
- W2000483770 hasConceptScore W2000483770C89423630 @default.
- W2000483770 hasIssue "1" @default.
- W2000483770 hasLocation W20004837701 @default.
- W2000483770 hasLocation W20004837702 @default.
- W2000483770 hasOpenAccess W2000483770 @default.
- W2000483770 hasPrimaryLocation W20004837701 @default.
- W2000483770 hasRelatedWork W10007496 @default.
- W2000483770 hasRelatedWork W1978844459 @default.
- W2000483770 hasRelatedWork W2008910987 @default.
- W2000483770 hasRelatedWork W2013509971 @default.
- W2000483770 hasRelatedWork W2020333055 @default.
- W2000483770 hasRelatedWork W2040834056 @default.
- W2000483770 hasRelatedWork W2140733491 @default.
- W2000483770 hasRelatedWork W2401291924 @default.
- W2000483770 hasRelatedWork W2950850055 @default.
- W2000483770 hasRelatedWork W4311646538 @default.
- W2000483770 hasVolume "30" @default.
- W2000483770 isParatext "false" @default.
- W2000483770 isRetracted "false" @default.
- W2000483770 magId "2000483770" @default.
- W2000483770 workType "article" @default.