Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000486385> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2000486385 endingPage "769" @default.
- W2000486385 startingPage "762" @default.
- W2000486385 abstract "Both the estrogen responsiveness and -binding capacity of cultured rat uterine cells were decreased dramatically when the medium was not changed at 24-h intervals. Treatment of cells for 24 h with 1 nM 17β-estradiol in fresh medium led to a 3-fold increase in progesterone receptor concentration, but without fresh medium, no increase in progesterone receptors was observed. When the medium was changed on cells with a low estrogen-binding capacity (depleted cells), a 6- to 10-fold increase in estrogen-binding capacity (to in vivo levels) occurred within 24 h (fed cells), and total protein was increased 2-fold. The high and low affinity binding characteristics of fed and depleted cells were identical. Recovery of the estrogen-binding capacity of depleted cells was relatively slow, increasing after a 6-h lag and reaching maximal levels by 24 h. While 6 h of 10−5M cycloheximide treatment (protein synthesis inhibited >95%) had little effect on control estrogen binding levels, it completely inhibited the increase in the estrogen-binding capacity induced by changing the medium on depleted cells. These results indicate that estrogen-binding activity can be varied in cultured rat uterine cells by changing medium conditions and suggest that these changes are due to differences in receptor protein levels and not to a receptor activation-inactivation phenomenon. (Endocrinology 115: 762–769,1984)" @default.
- W2000486385 created "2016-06-24" @default.
- W2000486385 creator A5041677430 @default.
- W2000486385 creator A5069785361 @default.
- W2000486385 creator A5088694477 @default.
- W2000486385 date "1984-08-01" @default.
- W2000486385 modified "2023-10-17" @default.
- W2000486385 title "Estrogen Receptors in Rat Uterine Cell Cultures: Effects of Medium on Receptor Concentration*" @default.
- W2000486385 cites W1482092913 @default.
- W2000486385 cites W1516397282 @default.
- W2000486385 cites W1523493483 @default.
- W2000486385 cites W1577865969 @default.
- W2000486385 cites W1607871381 @default.
- W2000486385 cites W1665170788 @default.
- W2000486385 cites W1864176760 @default.
- W2000486385 cites W1906197854 @default.
- W2000486385 cites W1977707545 @default.
- W2000486385 cites W1978432676 @default.
- W2000486385 cites W1982456184 @default.
- W2000486385 cites W1983938859 @default.
- W2000486385 cites W1988941884 @default.
- W2000486385 cites W2008519086 @default.
- W2000486385 cites W2012855221 @default.
- W2000486385 cites W2015852574 @default.
- W2000486385 cites W2053173024 @default.
- W2000486385 cites W2053772094 @default.
- W2000486385 cites W2065535541 @default.
- W2000486385 cites W2073047076 @default.
- W2000486385 cites W2073553829 @default.
- W2000486385 cites W2090929877 @default.
- W2000486385 cites W2093755100 @default.
- W2000486385 cites W2094104824 @default.
- W2000486385 cites W2106711602 @default.
- W2000486385 cites W2124642053 @default.
- W2000486385 cites W2127954353 @default.
- W2000486385 cites W2128635872 @default.
- W2000486385 cites W2139636738 @default.
- W2000486385 cites W2139716732 @default.
- W2000486385 cites W2234832455 @default.
- W2000486385 doi "https://doi.org/10.1210/endo-115-2-762" @default.
- W2000486385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6745180" @default.
- W2000486385 hasPublicationYear "1984" @default.
- W2000486385 type Work @default.
- W2000486385 sameAs 2000486385 @default.
- W2000486385 citedByCount "29" @default.
- W2000486385 countsByYear W20004863852017 @default.
- W2000486385 countsByYear W20004863852023 @default.
- W2000486385 crossrefType "journal-article" @default.
- W2000486385 hasAuthorship W2000486385A5041677430 @default.
- W2000486385 hasAuthorship W2000486385A5069785361 @default.
- W2000486385 hasAuthorship W2000486385A5088694477 @default.
- W2000486385 hasConcept C121608353 @default.
- W2000486385 hasConcept C126322002 @default.
- W2000486385 hasConcept C134018914 @default.
- W2000486385 hasConcept C153911025 @default.
- W2000486385 hasConcept C170493617 @default.
- W2000486385 hasConcept C185592680 @default.
- W2000486385 hasConcept C2777164284 @default.
- W2000486385 hasConcept C2778128677 @default.
- W2000486385 hasConcept C3675279 @default.
- W2000486385 hasConcept C530470458 @default.
- W2000486385 hasConcept C71924100 @default.
- W2000486385 hasConcept C84606932 @default.
- W2000486385 hasConcept C86803240 @default.
- W2000486385 hasConceptScore W2000486385C121608353 @default.
- W2000486385 hasConceptScore W2000486385C126322002 @default.
- W2000486385 hasConceptScore W2000486385C134018914 @default.
- W2000486385 hasConceptScore W2000486385C153911025 @default.
- W2000486385 hasConceptScore W2000486385C170493617 @default.
- W2000486385 hasConceptScore W2000486385C185592680 @default.
- W2000486385 hasConceptScore W2000486385C2777164284 @default.
- W2000486385 hasConceptScore W2000486385C2778128677 @default.
- W2000486385 hasConceptScore W2000486385C3675279 @default.
- W2000486385 hasConceptScore W2000486385C530470458 @default.
- W2000486385 hasConceptScore W2000486385C71924100 @default.
- W2000486385 hasConceptScore W2000486385C84606932 @default.
- W2000486385 hasConceptScore W2000486385C86803240 @default.
- W2000486385 hasIssue "2" @default.
- W2000486385 hasLocation W20004863851 @default.
- W2000486385 hasLocation W20004863852 @default.
- W2000486385 hasOpenAccess W2000486385 @default.
- W2000486385 hasPrimaryLocation W20004863851 @default.
- W2000486385 hasRelatedWork W1982850748 @default.
- W2000486385 hasRelatedWork W200925908 @default.
- W2000486385 hasRelatedWork W2087504465 @default.
- W2000486385 hasRelatedWork W2117019370 @default.
- W2000486385 hasRelatedWork W2335928397 @default.
- W2000486385 hasRelatedWork W2364285896 @default.
- W2000486385 hasRelatedWork W3010551324 @default.
- W2000486385 hasRelatedWork W3209895153 @default.
- W2000486385 hasRelatedWork W4252776767 @default.
- W2000486385 hasRelatedWork W2171150728 @default.
- W2000486385 hasVolume "115" @default.
- W2000486385 isParatext "false" @default.
- W2000486385 isRetracted "false" @default.
- W2000486385 magId "2000486385" @default.
- W2000486385 workType "article" @default.