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• W2000488096 abstract "Aim of the study Although patient and tumour characteristics are the most important determinants for outcomes in rectal cancer care, actionable factors for improving these are still unclear. Therefore, the purpose of this study was to assess the impact of surgeon and hospital factors which can actually be influenced to improve on postoperative complications, disease-free survival (DFS) and relative survival (RS) in rectal cancer. Methods For 819 curatively operated rectal cancer patients, staged I–III and diagnosed between 2001 and 2005, data were derived from the population-based Cancer Registry of the Comprehensive Cancer Centre North East and supplemented by medical record examination. (Multilevel) Logistic regression analysis was performed to examine the influence of relevant factors on postoperative complications and time from diagnosis to first treatment. Besides, Cox regression analysis for DFS and relative survival analysis was performed. Results Postoperative complications were dependent on type of surgery (p = 0.024) and hospital volume (p = 0.029). DFS was mainly influenced by stage (p < 0.001) and time to treatment (p = 0.018). Actionable indicators related to RS were type of surgery (p = 0.011) and time to treatment (p = 0.048). Time to treatment was found to be related to co-morbidity (p = 0.007), preoperative radiotherapy (p = 0.003) and referral for operation (p = 0.048). Nevertheless, 18.2% unexplained variation in time to treatment remained on hospital level. Conclusions We conclude that optimal outcomes for rectal cancer care can be achieved by focusing on early detection and timely diagnosis, as well as adequate choice and timeliness of treatment in hospitals with optimal logistics for rectal cancer patients." @default.
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• W2000488096 date "2010-07-01" @default.
• W2000488096 modified "2023-10-18" @default.
• W2000488096 title "Actionable indicators for short and long term outcomes in rectal cancer" @default.
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• W2000488096 doi "https://doi.org/10.1016/j.ejca.2010.02.044" @default.
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