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- W2000488292 abstract "Monolayer tissue cultures were performed from the center and from the periphery of large human osteogenic sarcomas, before and 4 to 5 months after a radical course of radiation therapy. Successful and continuous growth was maintained throughout several passages in the pre-irradiation material from the central and from the peripheral compartments. At 5 months postirradiation, no viable cells capable of dividing were present in the irradiated central compartments while the irradiated cells from the periphery of one of the tumors grew for three consecutive generations. These findings are in contrast with current radiobiologic principles that cells in the periphery of large tumors are more radiosensitive than those in the center. However, it correlates well with our previous animal experimental evidence that in some tumors the central compartment is not the most radioresistant." @default.
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- W2000488292 date "1973-06-01" @default.
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- W2000488292 title "Radiation damage to the periphery and center of human osteogenic sarcoma" @default.
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- W2000488292 doi "https://doi.org/10.1002/1097-0142(197306)31:6<1354::aid-cncr2820310608>3.0.co;2-x" @default.
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